Department of Anaesthesia and Perioperative Medicine, Royal Hobart Hospital, Hobart, Australia.
Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia.
Anaesth Intensive Care. 2021 Nov;49(6):440-447. doi: 10.1177/0310057X211002838. Epub 2021 Oct 17.
Prophylactic administration of uterotonics ensures adequate uterine contraction at elective caesarean section to prevent substantial haemorrhage. Royal College of Obstetricians and Gynaecologists guidelines advise the administration of oxytocin at 5 IU as a 'slow bolus' but there are variations in clinical practice. This study aimed to determine the beliefs and uterotonic usage practices at elective caesarean section by surveying anaesthetist members of the Obstetric Anaesthesia Special Interest Group in Australia and New Zealand. Questionnaires were emailed to Obstetric Anaesthesia Special Interest Group members and the response rate was 33%, with analysis of 279 completed reports. Oxytocin was the most commonly used first-line uterotonic, but extensive variation in oxytocin bolus use was identified. Thirty-eight per cent of anaesthetists routinely administered Royal College of Obstetricians and Gynaecologists guideline-recommended 5 IU, whereas 38% favoured low dose (<5 IU), 10% high dose (≥10 IU) oxytocin and 13% carbetocin (100 µg). More than 50% felt the evidence was weak for guideline-recommended 5 IU. Wide variation in the duration of oxytocin administration was also identified. Fifty-eight per cent of anaesthetists routinely gave follow-up oxytocin infusions, most commonly at 40 IU over 4 hours, but there was significant variation in the dosage (10-40 IU) and administration duration (1 hour to ≥6 hours). In conclusion, there is significant variation in oxytocin usage practices at elective caesarean section among Australian and New Zealand anaesthetists. This variation may be due to a lack of strong evidence to guide practice. This emphasises the need for high quality trials in this clinically important area.
预防性使用子宫收缩剂可确保选择性剖宫产时子宫充分收缩,以防止大量出血。皇家妇产科医师学院的指南建议给予催产素 5IU 作为“缓慢推注”,但临床实践存在差异。本研究旨在通过调查澳大利亚和新西兰产科麻醉学专业兴趣小组成员的麻醉师,确定他们在选择性剖宫产时的信念和缩宫素使用情况。向产科麻醉学专业兴趣小组成员发送了电子邮件问卷,回复率为 33%,对 279 份完成的报告进行了分析。催产素是最常用的一线缩宫素,但催产素推注的使用存在广泛差异。38%的麻醉师常规给予皇家妇产科医师学院指南推荐的 5IU,而 38%的麻醉师倾向于低剂量(<5IU),10%的麻醉师倾向于高剂量(≥10IU)催产素,13%的麻醉师倾向于卡贝缩宫素(100µg)。超过 50%的麻醉师认为指南推荐的 5IU 证据较弱。催产素给药持续时间也存在广泛差异。58%的麻醉师常规给予后续催产素输注,最常见的剂量为 40IU 持续 4 小时,但剂量(10-40IU)和给药持续时间(1 小时至≥6 小时)存在显著差异。总之,澳大利亚和新西兰麻醉师在选择性剖宫产中使用催产素的做法存在显著差异。这种差异可能是由于缺乏指导实践的有力证据。这强调了在这个临床重要领域进行高质量试验的必要性。