合成 1-取代的吩嗪类化合物作为新型抗衣原体药物。

Synthesis of 1-substituted phenazines as novel antichlamydial agents.

机构信息

School of Pharmacy, Nantong University, Nantong 226001, China.

出版信息

J Asian Nat Prod Res. 2022 Sep;24(9):827-838. doi: 10.1080/10286020.2021.1982909. Epub 2021 Oct 16.

DOI:10.1080/10286020.2021.1982909

Abstract

A novel series of 1-substituted phenazines - were designed and synthesized Palladium-catalyzed reactions from 1-phenazine trifluoromethanesulfonate. These phenazines showed antichlamydial activity with IC values from 1 to 10 μM. Among them, compounds and exhibited the best antichlamydial activity with IC values from 2.06 to 2.74 μM without apparent cytotoxicity to host cells.

摘要

我们设计并合成了一系列新型 1-取代苯并嗪，通过钯催化 1-苯并嗪三氟甲磺酸酯的反应得到。这些苯并嗪表现出抗衣原体活性，IC 值为 1 至 10 μM。其中，化合物和表现出最好的抗衣原体活性，IC 值为 2.06 至 2.74 μM，对宿主细胞没有明显的细胞毒性。