蛹虫草素衍生物的合成、抗肿瘤和抗菌活性。
Synthesis, antitumor and antibacterial activities of cordycepin derivatives.
机构信息
School of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029, China.
Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, China.
出版信息
J Asian Nat Prod Res. 2022 Sep;24(9):849-859. doi: 10.1080/10286020.2021.1982907. Epub 2021 Oct 16.
Twelve novel cordycepin derivatives were designed and synthesized with modification at positions of 2', 5'-hydroxyl and amino groups of cordycepin. The results showed that the inhibitory activities of , , and on A549 were comparable to the positive control gefitinib, and the inhibitory activity of on A549 was better than that of gefitinib. Also, the inhibitory activities of twelve cordycepin derivatives against 1924, 4220 and 3289 were studied. Among them, showed certain inhibitory on , while showed certain inhibition on .
设计并合成了 12 种新型蛹虫草素衍生物，对蛹虫草素 2'、5'-羟基和氨基进行了修饰。结果表明，化合物 、 、 和 对 A549 的抑制活性与阳性对照药吉非替尼相当，化合物 对 A549 的抑制活性优于吉非替尼。同时，还研究了 12 种蛹虫草素衍生物对 1924、4220 和 3289 的抑制活性。其中，化合物 对 显示出一定的抑制作用，而化合物 对 显示出一定的抑制作用。
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