主观认知下降伴和不伴担忧组间功能性脑网络差异：来自 SILCODE 的图论研究。

Differences in Functional Brain Networks Between Subjective Cognitive Decline with and without Worry Groups: A Graph Theory Study from SILCODE.

机构信息

Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China.

Institute of Biomedical Engineering, School of Communication and Information Engineering, Shanghai University, Shanghai, China.

出版信息

J Alzheimers Dis. 2021;84(3):1279-1289. doi: 10.3233/JAD-215156.

DOI:10.3233/JAD-215156

PMID:34657889

Abstract

BACKGROUND

Evidence suggests that subjective cognitive decline (SCD) individuals with worry have a higher risk of cognitive decline. However, how SCD-related worry influences the functional brain network is still unknown.

OBJECTIVE

In this study, we aimed to explore the differences in functional brain networks between SCD subjects with and without worry.

METHODS

A total of 228 participants were enrolled from the Sino Longitudinal Study on Cognitive Decline (SILCODE), including 39 normal control (NC) subjects, 117 SCD subjects with worry, and 72 SCD subjects without worry. All subjects completed neuropsychological assessments, APOE genotyping, and resting-state functional magnetic resonance imaging (rs-fMRI). Graph theory was applied for functional brain network analysis based on both the whole brain and default mode network (DMN). Parameters including the clustering coefficient, shortest path length, local efficiency, and global efficiency were calculated. Two-sample T-tests and chi-square tests were used to analyze differences between two groups. In addition, a false discovery rate-corrected post hoc test was applied.

RESULTS

Our analysis showed that compared to the SCD without worry group, SCD with worry group had significantly increased functional connectivity and shortest path length (p = 0.002) and a decreased clustering coefficient (p = 0.013), global efficiency (p = 0.001), and local efficiency (p < 0.001). The above results appeared in both the whole brain and DMN.

CONCLUSION

There were significant differences in functional brain networks between SCD individuals with and without worry. We speculated that worry might result in alterations of the functional brain network for SCD individuals and then result in a higher risk of cognitive decline.

摘要

背景

有证据表明，有担忧情绪的主观认知下降（SCD）个体认知下降的风险更高。然而，SCD 相关的担忧如何影响功能脑网络仍不清楚。

目的

本研究旨在探讨有和无担忧的 SCD 受试者之间功能脑网络的差异。

方法

共纳入 228 名来自中国认知衰退纵向研究（SILCODE）的参与者，包括 39 名正常对照（NC）受试者、117 名有担忧的 SCD 受试者和 72 名无担忧的 SCD 受试者。所有受试者均完成了神经心理学评估、APOE 基因分型和静息态功能磁共振成像（rs-fMRI）。基于全脑和默认模式网络（DMN），应用图论进行功能脑网络分析。计算了聚类系数、最短路径长度、局部效率和全局效率等参数。采用两样本 t 检验和卡方检验对两组间的差异进行分析。此外，还应用了错误发现率校正的事后检验。