Key Laboratory of Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400044, P. R. China.
Chongqing Key Laboratory of Bio-perception & Intelligent Information Processing, School of Microelectronics and Communication Engineering, Chongqing University, Chongqing, 400044, P. R. China.
J Mater Chem B. 2021 Nov 10;9(43):9031-9040. doi: 10.1039/d1tb01120k.
Integrating metal-organic frameworks (MOFs) of different components or structures together and exploiting them as electrochemical sensors for electrochemical sensing has aroused great interest. Furthermore, the incorporation of noble metals with MOFs is conducive to the improvement of catalytic performance. In this work, Pd@UiO-66-on-ZIF-L nanomaterials were successfully synthesised onto a self-supported flexible carbon cloth (Pd@UiO-66-on-ZIF-L/CC) through a novel strategy called MOF-on-MOF. Then, Au nanoparticles were electrodeposited onto Pd@UiO-66-on-ZIF-L/CC to obtain Au-Pd@UiO-66-on-ZIF-L/CC, which can serve as an excellent electrocatalyst for the reduction of hydrogen peroxide (HO). The obtained flower-like Pd@UiO-66-on-ZIF-L/CC hybrid MOF changes the structure of the monomeric MOF alone and adds more attachment sites. The synergy of the bimetals greatly improved the catalytic performance of the as-developed sensor. Electrochemical experiment results show that the proposed sensor based on Au-Pd@UiO-66-on-ZIF-L/CC has an extended linear range from 1 μM to 19.6 mM with a sensitivity of 390 μA mM cm, and a low limit of detection (LOD) of 21.2 nM (/ = 3). Moreover, it has good anti-interference, reproducibility, repeatability and excellent stability. Furthermore, the real-time detection of HO secreted from human adenocarcinomic alveolar basal epithelial cells (A549 cells) was achieved by culturing cells on Au-Pd@UiO-66-on-ZIF-L/CC, which indicates the potential of the sensor for applications in cancer pathology. Both the synthesis strategy and the sensor design provide new methods and ideas for the production of ultrasensitive HO electrochemical sensors.
将不同组分或结构的金属-有机骨架（MOFs）集成在一起，并将其用作电化学传感器进行电化学传感，引起了极大的兴趣。此外，将贵金属与 MOFs 结合有利于提高催化性能。在这项工作中，通过一种称为 MOF-on-MOF 的新策略，成功地将 Pd@UiO-66-on-ZIF-L 纳米材料合成到自支撑柔性碳纤维布（Pd@UiO-66-on-ZIF-L/CC）上。然后，将金纳米颗粒电沉积到 Pd@UiO-66-on-ZIF-L/CC 上，得到 Au-Pd@UiO-66-on-ZIF-L/CC，可作为过氧化氢（HO）还原的优异电催化剂。所得花状 Pd@UiO-66-on-ZIF-L/CC 杂化 MOF 改变了单体 MOF 的结构，并增加了更多的附着位点。双金属的协同作用极大地提高了所开发传感器的催化性能。电化学实验结果表明，基于 Au-Pd@UiO-66-on-ZIF-L/CC 的传感器具有从 1 μM 到 19.6 mM 的扩展线性范围，灵敏度为 390 μA mM cm，检测限（LOD）低至 21.2 nM（/ = 3）。此外，它具有良好的抗干扰性、重现性、重复性和优异的稳定性。此外，通过在 Au-Pd@UiO-66-on-ZIF-L/CC 上培养细胞，实现了对人腺癌细胞（A549 细胞）分泌的 HO 的实时检测，这表明该传感器在癌症病理学中的应用潜力。合成策略和传感器设计为生产超灵敏 HO 电化学传感器提供了新的方法和思路。
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