Arya Lima, Sundriyal Deepak, Bhandari Rekha, Srivastava Ruchi, Sehrawat Amit
Max Superspeciality Hospital, New Delhi, India.
All India Institute of Medical Sciences, Rishikesh, Uttarakhand India.
Indian J Surg Oncol. 2021 Sep;12(3):545-548. doi: 10.1007/s13193-021-01377-7. Epub 2021 Jun 29.
Solid organ cancers infrequently metastasize to bone marrow (BM). BM involvement by cancer in adults leads to poor prognosis and it becomes difficult to provide appropriate treatment. We aimed to study the clinical, pathological and radiological characteristics of adult patients with BM involvement at our institute. Eleven adult patients diagnosed with BM involvement associated with solid organ cancer were included in the study. Clinical, laboratory, radiological and treatment details were analysed. Carcinoma of the breast accounted for majority of the cases. Most of the patients had poor performance status (PS) at diagnosis. Serum lactate dehydrogenase (LDH) was found to be elevated in all cases. Serum alkaline phosphatase (ALP) was elevated in all except 1 case. Median overall survival (OS) was 91 days. BM involvement from solid organ cancer in adults predicts a poor outcome. Serum LDH and serum ALP can serve as a marker of BM involvement.
实体器官癌症很少转移至骨髓（BM）。成人癌症累及骨髓会导致预后不良，且难以提供恰当的治疗。我们旨在研究我院成年骨髓受累患者的临床、病理和放射学特征。本研究纳入了11例诊断为与实体器官癌症相关的骨髓受累成年患者。分析了临床、实验室、放射学及治疗细节。乳腺癌占大多数病例。大多数患者在诊断时体能状态（PS）较差。所有病例血清乳酸脱氢酶（LDH）均升高。除1例患者外，其余患者血清碱性磷酸酶（ALP）均升高。中位总生存期（OS）为91天。成人实体器官癌症累及骨髓预示预后不良。血清LDH和血清ALP可作为骨髓受累的标志物。
