Atagün Murat İlhan, Oral Timuçin
Department of Psychiatry, İzmir Bakırçay University Faculty of Medicine, İzmir, Turkey.
Private Practice, İstanbul, Turkey.
Noro Psikiyatr Ars. 2021 Sep 20;58(Suppl 1):S24-S30. doi: 10.29399/npa.27411. eCollection 2021.
Bipolar disorder is a disabling psychiatric disorder which causes premature death and loss of quality of life. Despite the developments, novel treatments are partially effective and insufficient responses to treatment may cause loss of quality of life. Contemporary approaches to treatment planning involve taking the current symptoms and the personal treatment history of the patient into account and tailoring them for the treatment of each patient, i.e. individualized treatment. In this article, effects and side effects of antipsychotics, mood stabilizers and sedative hypnotic medications are reviewed and presented briefly for clinicians. Although novel developments have been observed in the literature about mixed states and psychotic symptoms, evidence-based options are still limited. Efficacy of mood stabilizers may be prolonged and additional medications may also be needed frequently in patients treated with mood stabilizers. Antipsychotics may cause several side effects and cannot be maintained for a long time in some of those patients. These factors may limit the use of mood stabilizers or antipsychotics. Therefore, the experience of the clinician and personal history of the patient still have importance in the procedure.
双相情感障碍是一种致残性精神疾病，会导致过早死亡和生活质量下降。尽管有了进展，但新型治疗方法只是部分有效，对治疗的反应不足可能会导致生活质量下降。当代的治疗计划方法包括考虑患者当前的症状和个人治疗史，并为每个患者量身定制治疗方案，即个体化治疗。在本文中，将为临床医生简要回顾和介绍抗精神病药物、心境稳定剂和镇静催眠药物的疗效及副作用。尽管在关于混合状态和精神病性症状的文献中已观察到新进展，但基于证据的选择仍然有限。心境稳定剂的疗效可能会延长，使用心境稳定剂治疗的患者也常常可能需要加用其他药物。抗精神病药物可能会引起多种副作用，并且在一些患者中不能长期使用。这些因素可能会限制心境稳定剂或抗精神病药物的使用。因此，临床医生的经验和患者的个人史在治疗过程中仍然很重要。
