Horie R, Kihara M, Lovenberg W, Ben-Ishay D, Bianchi G, Iwai J, Nagaoka A, Rapp J P, Sassard J, Simpson F O
J Hypertens Suppl. 1986 Oct;4(3):S11-4.
Comparative studies on nine genetic hypertensive rat strains [two stroke-prone spontaneously hypertensive rats (SHRSP) and Dahl salt-sensitive (DS) strains, and one strain each of spontaneously hypertensive rats (SHR), Lyon hypertensive rats (LH), Milan hypertensive strain (MHS), genetically hypertensive rats (GH) and Sabra hypertensive rats (SBH)] and their respective controls [two Dahl salt-resistent (DR) strains and one strain each of Wistar-Kyoto rats (WKY), Lyon normotensive rats (LN); Lyon low blood pressure rats (LL), Milan normotensive strain (MNS), genetically normotensive rats (GN) and Sabra normotensive rats (SBN) and their original strain, Sabra rats (SB)], in groups consisting of 6-10 males from each strain, were carried out at 10-12 weeks of age under the same experimental conditions. After checking the developmental course of blood pressure and changes in body weight, they were killed at 12 weeks of age for blood analysis and organ-weight examinations. The SHRSP and SHR showed markedly higher blood pressure levels and earlier blood pressure rises in comparison with other hypertensive strains, although they had higher blood pressure than their respective controls. Among various organ weights examined, all hypertensive strains commonly showed increases in left ventricular weight in proportion to blood pressure rises. Kidney weights were significantly decreased only in MHS compared with MNS, while they were either unchanged or significantly greater in other hypertensive strains. Weights of adrenal glands were greater in the two strains of DS and in LH than in their respective control strains. These comparative data indicate possible differences in the pathogenic mechanism involved in these genetic hypertensive rat strains.
对九种遗传性高血压大鼠品系[两种易中风自发性高血压大鼠（SHRSP）和 Dahl 盐敏感（DS）品系，以及自发性高血压大鼠（SHR）、里昂高血压大鼠（LH）、米兰高血压品系（MHS）、遗传性高血压大鼠（GH）和萨布拉高血压大鼠（SBH）各一种品系]及其相应对照[两种 Dahl 盐抵抗（DR）品系和 Wistar-Kyoto 大鼠（WKY）、里昂正常血压大鼠（LN）、里昂低血压大鼠（LL）、米兰正常血压品系（MNS）、遗传性正常血压大鼠（GN）和萨布拉正常血压大鼠（SBN）各一种品系以及它们的原始品系萨布拉大鼠（SB）]进行了比较研究，每组由来自每个品系的 6 - 10 只雄性大鼠组成，在相同实验条件下于 10 - 12 周龄时进行。在检查血压的发育过程和体重变化后，于 12 周龄时处死它们进行血液分析和器官重量检查。与其他高血压品系相比，SHRSP 和 SHR 的血压水平明显更高且血压升高更早，尽管它们的血压高于各自的对照。在检查的各种器官重量中，所有高血压品系通常都显示左心室重量随血压升高成比例增加。与 MNS 相比，仅 MHS 的肾脏重量显著降低，而其他高血压品系的肾脏重量要么不变要么显著增加。DS 的两个品系和 LH 的肾上腺重量比它们各自的对照品系更大。这些比较数据表明这些遗传性高血压大鼠品系所涉及的致病机制可能存在差异。
