Kawashima H, Sokabe H
J Hypertens Suppl. 1986 Oct;4(3):S287-9.
To test the possible impairment of vitamin D metabolism in hypertension, we studied the effect of parathyroid hormone (PTH) on the renal production of 1,25-dihydroxyvitamin D [1,25(OH)2D] in spontaneously hypertensive rats (SHR) before (at 4 weeks of age) and after (at 12 weeks of age) the onset of hypertension. Basal serum of 1,25(OH)2D was normal in SHR at both ages. At 4 weeks of age, rise in serum 1,25(OH)2D following PTH injection (50 U subcutaneously every 2 h, four times) was also normal in SHR. By contrast, at 12 weeks of age it was approximately one-third of that in Wistar-Kyoto rats (WKY) in parallel with an attenuated response to PTH of renal production of 1,25(OH)2D. Basal 1,25(OH)2D production by the kidney in SHR was higher than that in WKY at both ages, which was abolished by thyroparathyroidectomy but not by parathyroidectomy. These data demonstrate that altered vitamin D metabolism exists even before the onset of hypertension in SHR.
为了检测高血压患者维生素D代谢可能存在的损害，我们研究了甲状旁腺激素（PTH）对自发性高血压大鼠（SHR）在高血压发作前（4周龄）和发作后（12周龄）肾脏产生1,25 - 二羟维生素D [1,25(OH)₂D]的影响。两个年龄段的SHR基础血清1,25(OH)₂D均正常。4周龄时，SHR经PTH注射（每2小时皮下注射50 U，共4次）后血清1,25(OH)₂D的升高也正常。相比之下，12周龄时，其升高幅度约为Wistar - Kyoto大鼠（WKY）的三分之一，同时肾脏产生1,25(OH)₂D对PTH的反应减弱。两个年龄段SHR肾脏基础1,25(OH)₂D的产生均高于WKY，甲状腺甲状旁腺切除可消除这种差异，但甲状旁腺切除则不能。这些数据表明，在SHR高血压发作之前就已经存在维生素D代谢改变。
