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三七皂苷通过抑制细胞周期中的G / G期以及影响p53介导的自噬和线粒体凋亡发挥抗骨肉瘤作用。

The anti-osteosarcoma effect from panax notoginseng saponins by inhibiting the G / G phase in the cell cycle and affecting p53-mediated autophagy and mitochondrial apoptosis.

作者信息

Han Guangtao, Zhang Yubiao, Liu Ting, Li Jianping, Li Haohuan

机构信息

Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.

Department of Orthopedics, Hospital of Shenmu, Shenmu, Shaanxi, 719300, P.R. China.

出版信息

J Cancer. 2021 Aug 30;12(21):6383-6392. doi: 10.7150/jca.54602. eCollection 2021.

DOI:10.7150/jca.54602
PMID:34659528
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8489146/
Abstract

Osteosarcoma is the most common primary bone malignancy, and current chemotherapy sessions against it often induce severe complications in patients. Thus, it is necessary to develop new and effective antineoplastic agents with fewer side effects. Panax notoginseng saponins (PNS) are the active components in panax notoginseng and were reported to be capable of inhibiting the growth of several tumors both in vitro and in vivo. However, its effects on osteosarcoma have not been studied yet, which is addressed in this study for the first time. Our results indicated that PNS can inhibit proliferation, invasion and migration of the osteosarcoma cells, while promoting their apoptosis simultaneously. Specifically, PNS caused an increase in mitochondrial membrane potential and the amount of reactive oxygen species. The cell cycle in osteosarcoma cells was arrested in the G0 / G1 phase after PNS treatment. The expression of p53 and other apoptosis-related mitochondrial proteins were promoted. Nevertheless, it was observed that autophagy became less active in osteosarcoma cells when PNS was administered. In a word, PNS were of potential therapeutic significance for osteosarcoma.

摘要

骨肉瘤是最常见的原发性骨恶性肿瘤，目前针对骨肉瘤的化疗疗程常常会给患者带来严重并发症。因此，有必要研发副作用更少的新型有效抗肿瘤药物。三七皂苷（PNS）是三七中的活性成分，据报道其在体外和体内均能抑制多种肿瘤的生长。然而，其对骨肉瘤的影响尚未见研究报道，本研究首次对此进行了探讨。我们的结果表明，PNS能抑制骨肉瘤细胞的增殖、侵袭和迁移，同时促进其凋亡。具体而言，PNS导致线粒体膜电位和活性氧含量增加。PNS处理后，骨肉瘤细胞的细胞周期停滞在G0 / G1期。p53及其他与凋亡相关的线粒体蛋白的表达增加。然而，观察到给予PNS时骨肉瘤细胞中的自噬活性降低。总之，PNS对骨肉瘤具有潜在的治疗意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f085/8489146/7cd60f78ada7/jcav12p6383g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f085/8489146/1cd9cb6349b7/jcav12p6383g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f085/8489146/7f5913d08289/jcav12p6383g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f085/8489146/f47f259eae19/jcav12p6383g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f085/8489146/313546e8c789/jcav12p6383g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f085/8489146/86bab8455c3a/jcav12p6383g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f085/8489146/7cd60f78ada7/jcav12p6383g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f085/8489146/1cd9cb6349b7/jcav12p6383g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f085/8489146/7f5913d08289/jcav12p6383g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f085/8489146/f47f259eae19/jcav12p6383g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f085/8489146/313546e8c789/jcav12p6383g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f085/8489146/86bab8455c3a/jcav12p6383g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f085/8489146/7cd60f78ada7/jcav12p6383g006.jpg

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[9]
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引用本文的文献

[1]
FAM60A promotes osteosarcoma development and progression.

Cancer Med. 2023-8

[2]
Suppresses Bone Morphogenetic Protein-2 Expression in EA.hy926 Endothelial Cells by Inhibiting the Noncanonical NF-κB and Wnt/β-Catenin Signaling Pathways.

Plants (Basel). 2022-11-28

[3]
Use of Saponinosomes from as Anticancer Drug Carriers.

ACS Omega. 2022-8-4

本文引用的文献

[1]
Influence of Canine Macrophage-derived Extracellular Vesicles on Apoptosis in Canine Melanoma and Osteosarcoma Cell Lines.

Anticancer Res. 2021-2

[2]
Water Extract of Sporoderm-Broken Spores of Induces Osteosarcoma Apoptosis and Restricts Autophagic Flux.

Onco Targets Ther. 2019-12-31

[3]
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Pharm Biol. 2020-12

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Advances in differentiation therapy for osteosarcoma.

Drug Discov Today. 2020-3

[5]
In-Vitro and In-Vivo Establishment and Characterization of Bioluminescent Orthotopic Chemotherapy-Resistant Human Osteosarcoma Models in NSG Mice.

Cancers (Basel). 2019-7-17

[6]
The ginsenoside Rk3 exerts anti-esophageal cancer activity in vitro and in vivo by mediating apoptosis and autophagy through regulation of the PI3K/Akt/mTOR pathway.

PLoS One. 2019-5-15

[7]
Ginsenoside Rh4 induces apoptosis and autophagic cell death through activation of the ROS/JNK/p53 pathway in colorectal cancer cells.

Biochem Pharmacol. 2017-12-7

[8]
Panax notoginseng saponins reduce high-risk factors for thrombosis through peroxisome proliferator-activated receptor -γ pathway.

Biomed Pharmacother. 2017-11-23

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Long non-coding RNA CTA sensitizes osteosarcoma cells to doxorubicin through inhibition of autophagy.

Oncotarget. 2017-5-9

[10]
Panax notoginseng saponins attenuate lung cancer growth in part through modulating the level of Met/miR-222 axis.

J Ethnopharmacol. 2016-12-4

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