Department of Nephrology, Dialysis and Kidney Transplantation, La Rabta Hospital, Tunis, Tunisia.
Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia.
Pan Afr Med J. 2021 Aug 16;39:243. doi: 10.11604/pamj.2021.39.243.30461. eCollection 2021.
Anti-glomerular basement membrane (anti-GBM) disease was usually described as a small vessel vasculitis presenting with acute kidney injury, haematuria and non-nephrotic proteinuria. We report a case of anti-GBM disease revealed by an intense nephrotic syndrome. The urinary protein level was 12g/day. Renal biopsy only showed crescent glomerulonephritis with linear staining of IgG in direct immunofluorescence without other glomerulonephritis. Immunoglobulin G (IgG) anti-GBM antibody titer was elevated.
抗肾小球基底膜（anti-GBM）病通常被描述为一种小血管血管炎，表现为急性肾损伤、血尿和非肾病性蛋白尿。我们报告一例由严重肾病综合征表现的抗肾小球基底膜病。尿蛋白水平为 12g/天。肾活检仅显示新月体性肾小球肾炎，直接免疫荧光法显示 IgG 线状染色，无其他肾小球肾炎。免疫球蛋白 G（IgG）抗肾小球基底膜抗体滴度升高。
