Maekawa T, Fujii H, Kashiwadani M, Suyama Y, Iwai M, Miyoshi M, Nishida K, Horiike S
Gan No Rinsho. 1986 Oct;32(12):1625-9.
A 68-year-old man with acute myelogenous leukemia (M2) was induced to complete remission by chemotherapy consisting of BH-AC and ACM-A on the 180th hospital day. Prior to therapy, chromosome analysis revealed 46, XY, del(5)(q22q33). No additional chromosome abnormalities were noted. Though 5q- was first associated with a preleukemic state, it is now known to be found in several different hematological disease. It has been suggested that patients with only a 5q- abnormality might have a better prognosis than those with a 5q- plus additional chromosome abnormalities. 5q- usually results from an interstitial deletion with break and fusion points at 5q11 or 12, 5q14 or 15, 5q22 and 5q33 or 35. The c-fms oncogene is located in the vicinity of band 5q34, so that a chromosome break at 5q33 or 34 may play an important role in the hematological disorders with 5q- chromosome abnormality.
一名68岁急性髓系白血病（M2型）男性患者在住院第180天时，通过由BH - AC和ACM - A组成的化疗诱导达到完全缓解。治疗前，染色体分析显示为46, XY, del(5)(q22q33)。未发现其他染色体异常。虽然5号染色体长臂缺失（5q-）最初与白血病前期状态相关，但现在已知在几种不同的血液系统疾病中均可发现。有人提出，仅存在5q-异常的患者可能比伴有5q-及其他染色体异常的患者预后更好。5q-通常是由5q11或12、5q14或15、5q22以及5q33或35处的断裂和融合点导致的中间缺失所致。原癌基因c - fms位于5q34带附近，因此5q33或34处的染色体断裂可能在伴有5q-染色体异常的血液系统疾病中起重要作用。
