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获得性血友病A继发球后出血

Retrobulbar Hemorrhage Secondary to Acquired Hemophilia A.

作者信息

Jayasundara Hishali D, Herath Lasitha Y, Kularatne Keertie S

机构信息

Medicine, National Hospital Kandy, Kandy, LKA.

出版信息

Cureus. 2021 Sep 6;13(9):e17760. doi: 10.7759/cureus.17760. eCollection 2021 Sep.

DOI:10.7759/cureus.17760
PMID:34659972
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8494152/
Abstract

Acquired hemophilia A (AHA) is a different bleeding disorder to that of classic hemophilia A. It is an autoimmune-mediated bleeding disorder due to the presence of autoantibodies (inhibitors) directed against plasma coagulation factor VIII. This can result in fatal hemorrhage; thus, eradication of the antibody is the mainstay of treatment. Nontraumatic retrobulbar hemorrhage is a very rare presentation of hemophilia. We report an elderly male presenting with retrobulbar hemorrhage secondary to AHA who was successfully treated with immunosuppression.

摘要

获得性血友病A（AHA）是一种与经典血友病A不同的出血性疾病。它是一种自身免疫介导的出血性疾病，由于存在针对血浆凝血因子VIII的自身抗体（抑制剂）。这可能导致致命性出血；因此，消除抗体是治疗的主要方法。非创伤性球后出血是血友病非常罕见的表现。我们报告一例继发于AHA的球后出血老年男性患者，经免疫抑制治疗成功治愈。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c43/8494152/61a9c088314c/cureus-0013-00000017760-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c43/8494152/dca1ee3b33ab/cureus-0013-00000017760-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c43/8494152/61a9c088314c/cureus-0013-00000017760-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c43/8494152/dca1ee3b33ab/cureus-0013-00000017760-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c43/8494152/61a9c088314c/cureus-0013-00000017760-i02.jpg

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本文引用的文献

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Hemophilia presenting as recurrent ocular hemorrhage.以反复眼部出血为表现的血友病。
GMS Ophthalmol Cases. 2020 Mar 18;10:Doc15. doi: 10.3205/oc000142. eCollection 2020.
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Immunosuppression for acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2).获得性血友病 A 的免疫抑制治疗：来自欧洲获得性血友病登记处（EACH2）的结果。
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