Bagchi Arindam, Khan Mohammad Saud, Saraswat Arti, Ansari Affan, Nai Qiang, Iyer Veena, Hamouda Danae, Khuder Sadik, Verghese Cherian
Oncology, Beckley Appalachian Regional Healthcare (ARH) Hospital, Beckley, USA.
Cardiology, University of Kentucky College of Medicine, Bowling Green, USA.
Cureus. 2021 Sep 6;13(9):e17769. doi: 10.7759/cureus.17769. eCollection 2021 Sep.
Venous thromboembolism (VTE) is a common complication in cancer patients and is associated with increased morbidity and mortality. Lung cancer is commonly associated with VTE including pulmonary embolism. We did a retrospective analysis from the 2013 Healthcare Cost and Utilization Project data to determine the role of age as a factor in the development of VTE in this patient group. Patients were selected using the International Classification of Diseases, Ninth Revision (ICD-9) diagnosis codes for metastatic lung cancer and VTE. The patients were stratified by age, sex, race/ethnicity, and site of VTE. There was a total of 16,577 VTE events detected out of a total of 182,863 cases of metastatic lung cancer, representing 9% of the total cases. In patients under 65 years of age, there were 356.82 more cases of pulmonary embolism per 100,000 individuals compared to those older than 65 years (p<0.0001). The same age group also showed 374.83 more upper extremity VTE, 286.94 more non-pulmonary thoracic VTE, and 263.97 more abdominal VTE events per 100,000 individuals (p<0.0001). In conclusion, we found that patients under the age of 65 years had a significantly higher incidence of VTE, pulmonary embolism, upper extremity VTE as well as abdominal and non-pulmonary VTE.
静脉血栓栓塞症（VTE）是癌症患者常见的并发症，与发病率和死亡率的增加相关。肺癌通常与包括肺栓塞在内的VTE相关。我们对2013年医疗成本与利用项目数据进行了回顾性分析，以确定年龄在此患者群体VTE发生发展中的作用。使用国际疾病分类第九版（ICD-9）诊断代码选择转移性肺癌和VTE患者。患者按年龄、性别、种族/民族和VTE部位进行分层。在总共182,863例转移性肺癌病例中，共检测到16,577例VTE事件，占总病例的9%。在65岁以下的患者中，每10万人中肺栓塞病例比65岁以上的患者多356.82例（p<0.0001）。同一年龄组每10万人中上肢VTE也多374.83例，非肺性胸部VTE多286.94例，腹部VTE事件多263.97例（p<0.0001）。总之，我们发现65岁以下的患者VTE、肺栓塞、上肢VTE以及腹部和非肺性VTE的发病率显著更高。
