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尿道狭窄与特应性状态:一项表明可能存在未明病因的初步研究

Meatal Stenosis and Atopic Condition: A Pilot Study Demonstrating a Possible Unidentified Etiology.

机构信息

Pediatric Urology and Regenerative Medicine Research Center, Section of Tissue Engineering and Stem Cells Therapy, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran AND Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Iran J Allergy Asthma Immunol. 2021 Sep 28;20(5):635-640. doi: 10.18502/ijaai.v20i5.7413.

DOI:10.18502/ijaai.v20i5.7413
PMID:34664822
Abstract

Meatal stenosis (MS) is known as one of the most frequent complications of circumcision. In the present study, we aimed to find any possible relationship between MS and allergic disorders. A total of 36 children with a mean±SD age of 5.84±2.03 years were referred with MS and an atopic background even in themselves or in one of their family members (Group A). There were also age-matched controls with a mean±SD age of 5.70±2.17 years who were referred to our center with allergic symptoms and no urinary complaints (Group B, n=17). The RIDA qLine allergy and allergy explorer (ALEX) tests were performed for all patients to find possible allergen sensitization. Laboratory findings revealed that IgE-sensitization to the main food and aeroallergens in Group A (with the chief complaint of MS in whom a mild atopic condition was found during concise medical history taking) were very similar to the control group with no significant difference (except for ryegrass which was higher in the control group). Although total IgE level was considerably higher in group B compared to group A, food sensitization to cow's milk and ß-lactoglobulin was higher in asthmatic patients of group A compared to the controls. It seems that not all patients with MS should be considered as a complication of circumcision and undergo a surgical procedure for correction of the stenosis. Further investigations are required to determine the role of concise medical history taking and proper treatment of the allergic disorder to reduce failed surgical attempts in atopic boys with MS.

摘要

尿道下裂是一种常见的先天性疾病,目前病因不明。有研究表明,尿道下裂可能与遗传、环境等多种因素有关。

尿道下裂的治疗方法主要包括手术治疗和非手术治疗。手术治疗是目前治疗尿道下裂的主要方法,可以有效改善患者的生活质量。非手术治疗主要包括药物治疗和心理治疗,可以缓解患者的症状,但不能根治疾病。

尿道下裂的手术治疗方法主要包括阴茎弯曲矫正术和尿道成形术。阴茎弯曲矫正术可以改善阴茎弯曲的程度,尿道成形术可以重建正常的尿道。

尿道下裂的治疗效果与患者的年龄、病情严重程度、治疗方法等因素有关。一般来说,早期治疗效果较好,晚期治疗效果较差。因此,对于尿道下裂的患者,应尽早进行治疗。

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