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[体外循环(ECLS/ECMO)在心脏和循环衰竭中的应用:S3指南简版]

[Use of extracorporeal circulation (ECLS/ECMO) for cardiac and circulatory failure : Short version of the S3 guideline].

作者信息

Boeken Udo, Ensminger Stephan, Assmann Alexander, Schmid Christof, Werdan Karl, Michels Guido, Miera Oliver, Schmidt Florian, Klotz Stefan, Starck Christoph, Pilarczyk Kevin, Rastan Ardawan, Burckhardt Marion, Nothacker Monika, Muellenbach Ralf, Zausig York, Haake Nils, Groesdonk Heinrich, Ferrari Markus, Buerke Michael, Hennersdorf Marcus, Rosenberg Mark, Schaible Thomas, Köditz Harald, Kluge Stefan, Janssens Uwe, Lubnow Matthias, Flemmer Andreas, Herber-Jonat Susanne, Wessel Lucas, Buchwald Dirk, Maier Sven, Krüger Lars, Fründ Andreas, Jaksties Rolf, Fischer Stefan, Wiebe Karsten, Hartog Christiane, Dzemali Omer, Zimpfer Daniel, Ruttmann-Ulmer Elfriede, Schlensak Christian, Kelm Malte, Beckmann Andreas

机构信息

Department of Cardiac Surgery, Heinrich Heine University Medical School, Moorenstraße 5, 40225, Düsseldorf, Deutschland.

Department of Cardiac and Thoracic Vascular Surgery, University Hospital of Schleswig-Holstein, Lübeck, Deutschland.

出版信息

Med Klin Intensivmed Notfmed. 2021 Nov;116(8):678-686. doi: 10.1007/s00063-021-00868-3.

DOI:10.1007/s00063-021-00868-3
PMID:34665281
Abstract

In Germany, a remarkable increase regarding the usage of extracorporeal membrane oxygenation (ECMO) and extracorporeal life support (ECLS) systems has been observed in recent years with approximately 3000 ECLS/ECMO implantations annually since 2015. Despite the widespread use of ECLS/ECMO, evidence-based recommendations or guidelines are still lacking regarding indications, contraindications, limitations and management of ECMO/ECLS patients. Therefore in 2015, the German Society of Thoracic and Cardiovascular Surgery (GSTCVS) registered the multidisciplinary S3 guideline "Use of extracorporeal circulation (ECLS/ECMO) for cardiac and circulatory failure" to develop evidence-based recommendations for ECMO/ECLS systems according to the requirements of the Association of the Scientific Medical Societies in Germany (AWMF). Although the clinical application of ECMO/ECLS represents the main focus, the presented guideline also addresses structural and economic issues. Experts from 17 German, Austrian and Swiss scientific societies and a patients' organization, guided by the GSTCVS, completed the project in February 2021. In this report, we present a summary of the methodological concept and tables displaying the recommendations for each chapter of the guideline.

摘要

近年来,德国体外膜肺氧合(ECMO)和体外生命支持(ECLS)系统的使用显著增加,自2015年以来,每年约有3000例ECLS/ECMO植入手术。尽管ECLS/ECMO得到了广泛应用,但在ECMO/ECLS患者的适应症、禁忌症、局限性和管理方面,仍缺乏循证医学推荐或指南。因此,2015年,德国胸心血管外科学会(GSTCVS)登记了多学科S3指南“体外循环(ECLS/ECMO)用于心脏和循环衰竭”,以根据德国科学医学协会联合会(AWMF)的要求,为ECMO/ECLS系统制定循证医学推荐。尽管ECMO/ECLS的临床应用是主要重点,但本指南也涉及结构和经济问题。在GSTCVS的指导下,来自17个德国、奥地利和瑞士科学协会以及一个患者组织的专家于2021年2月完成了该项目。在本报告中,我们总结了该指南各章节的方法学概念和推荐表格。

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本文引用的文献

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Survival after refractory cardiogenic shock is comparable in patients with Impella and veno-arterial extracorporeal membrane oxygenation when adjusted for SAVE score.在调整 SAVE 评分后,对于难治性心源性休克患者,使用 Impella 和静脉-动脉体外膜肺氧合治疗后的存活率相当。
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Simultaneous Venoarterial Extracorporeal Membrane Oxygenation and Percutaneous Left Ventricular Decompression Therapy with Impella Is Associated with Improved Outcomes in Refractory Cardiogenic Shock.在难治性心源性休克中,同时进行静脉-动脉体外膜肺氧合和 Impella 经皮左心室减压治疗与改善结局相关。
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2023年的体外心肺复苏术。
Intensive Care Med Exp. 2023 Oct 30;11(1):74. doi: 10.1186/s40635-023-00558-8.
4
Elevated lactate levels and impaired lactate clearance during extracorporeal life support (ECLS) are associated with poor outcome in cardiac surgery patients.体外生命支持(ECLS)期间乳酸水平升高和乳酸清除能力受损与心脏手术患者的不良预后相关。
PLoS One. 2022 Nov 28;17(11):e0278139. doi: 10.1371/journal.pone.0278139. eCollection 2022.
Position paper for the organization of ECMO programs for cardiac failure in adults.成人心力衰竭体外膜肺氧合治疗项目组织立场文件
Intensive Care Med. 2018 Jun;44(6):717-729. doi: 10.1007/s00134-018-5064-5. Epub 2018 Feb 15.
4
Heart Failure and Mortality of Adult Survivors from Acute Myocarditis Requiring Intensive Care Treatment - A Nationwide Cohort Study.急性心肌炎需重症监护治疗的成年幸存者的心力衰竭和死亡率:一项全国性队列研究。
Int J Med Sci. 2017 Sep 20;14(12):1241-1250. doi: 10.7150/ijms.20618. eCollection 2017.
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Volume-Outcome Relationships in Extracorporeal Membrane Oxygenation: Retrospective Analysis of Administrative Data From Pennsylvania, 2007-2015.体外膜肺氧合的量效关系:2007-2015 年宾夕法尼亚州行政数据的回顾性分析。
ASAIO J. 2018 Jul/Aug;64(4):450-457. doi: 10.1097/MAT.0000000000000675.
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Concomitant implantation of Impella on top of veno-arterial extracorporeal membrane oxygenation may improve survival of patients with cardiogenic shock.在静脉-动脉体外膜肺氧合(VA-ECMO)的基础上同时植入 Impella 可能会提高心源性休克患者的生存率。
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