Chantaraprateep P, Prateep P, Lohachit C, Poomsuwan P, Kunavongkrit A
Aust Vet J. 1986 Aug;63(8):254-6. doi: 10.1111/j.1751-0813.1986.tb02988.x.
This experiment was conducted in order to compare the effects of injecting PGF2 alpha alone, PGF2 alpha with oxytocin and placebo on the induction of farrowing in swine and to compare the relative effects of 3 different dosages of oxytocin (10, 20 and 30 iu per animal) when combined with PGF2 alpha (10 mg). The findings revealed that animals treated with 30 iu oxytocin farrowed within 10.6 h which was similar to those receiving PGF2 alpha only (9.4 h), but shorter than control animals (53.6 h). Animals receiving 20 and 10 iu of oxytocin farrowed within 1.4 and 1.7 h, respectively. Difficult farrowings requiring manual assistance occurred in 30%, 30%, 50% and 10% of sows given 30 iu, 20 iu and 10 iu of oxytocin and in the control group, respectively. Thirteen of 73 sows treated with PGF2 alpha farrowed within 12.6 +/- 5.3 h. Stillbirths were highest (10.2%) in the control animals whilst in the others it was under 7%. Oxytocin at dosages of 20 and 10 iu, seemed most promising in terms of synchronising farrowing following PGF2 alpha treatment in swine. However, farrowing complications were more common in these groups.
进行该实验是为了比较单独注射前列腺素F2α、前列腺素F2α与催产素联合使用以及安慰剂对诱导母猪分娩的影响，并比较三种不同剂量的催产素（每头动物10、20和30国际单位）与前列腺素F2α（10毫克）联合使用时的相对效果。研究结果显示，接受30国际单位催产素治疗的动物在10.6小时内分娩，这与仅接受前列腺素F2α治疗的动物（9.4小时）相似，但短于对照组动物（53.6小时）。接受20和10国际单位催产素的动物分别在1.4小时和1.7小时内分娩。在接受30国际单位、20国际单位和10国际单位催产素的母猪中，分别有30%、30%和50%以及对照组中有10%的母猪分娩困难需要人工辅助。73头接受前列腺素F2α治疗的母猪中有13头在12.6±5.3小时内分娩。对照组死产率最高（10.2%），而其他组低于7%。就同步母猪接受前列腺素F2α治疗后的分娩而言，20和10国际单位剂量的催产素似乎最有前景。然而，这些组中分娩并发症更为常见。
