Livestock Gentec, Department of Agriculture, Food and Nutritional Science, Faculty of Agricultural, Life and Environmental Sciences, University of Alberta, Edmonton, AB, Canada.
Department of Large Animal Clinical Sciences, University of Saskatchewan, Saskatoon, SK, Canada.
Sci Rep. 2021 Oct 19;11(1):20628. doi: 10.1038/s41598-021-99778-9.
Metabolites in plasma of healthy nursery pigs were quantified using nuclear magnetic resonance. Heritabilities of metabolite concentration were estimated along with their phenotypic and genetic correlations with performance, resilience, and carcass traits in growing pigs exposed to a natural polymicrobial disease challenge. Variance components were estimated by GBLUP. Heritability estimates were low to moderate (0.11 ± 0.08 to 0.19 ± 0.08) for 14 metabolites, moderate to high (0.22 ± 0.09 to 0.39 ± 0.08) for 17 metabolites, and highest for L-glutamic acid (0.41 ± 0.09) and hypoxanthine (0.42 ± 0.08). Phenotypic correlation estimates of plasma metabolites with performance and carcass traits were generally very low. Significant genetic correlation estimates with performance and carcass traits were found for several measures of growth and feed intake. Interestingly the plasma concentration of oxoglutarate was genetically negatively correlated with treatments received across the challenge nursery and finisher (- 0.49 ± 0.28; P < 0.05) and creatinine was positively correlated with mortality in the challenge nursery (0.85 ± 0.76; P < 0.05). These results suggest that some plasma metabolite phenotypes collected from healthy nursery pigs are moderately heritable and genetic correlations with measures of performance and resilience after disease challenge suggest they may be potential genetic indicators of disease resilience.
采用核磁共振技术对健康保育猪的血浆代谢物进行了定量分析。使用 GBLUP 估计了遗传方差和表型方差，并估计了在经历自然多微生物疾病挑战的生长猪中，代谢物浓度与其性能、弹性和胴体性状的表型和遗传相关性。遗传力估计值较低至中等（0.11±0.08 至 0.19±0.08），有 14 种代谢物，中等至高（0.22±0.09 至 0.39±0.08），有 17 种代谢物，L-谷氨酸（0.41±0.09）和次黄嘌呤（0.42±0.08）最高。血浆代谢物与性能和胴体性状的表型相关估计值通常非常低。与性能和胴体性状的遗传相关估计值在几个生长和饲料摄入量指标上有显著意义。有趣的是，在整个挑战保育和育肥期间，血浆草酰乙酸的浓度与所接受的处理呈负相关（-0.49±0.28；P<0.05），肌酐与保育期的死亡率呈正相关（0.85±0.76；P<0.05）。这些结果表明，从健康保育猪中收集的一些血浆代谢物表型具有中等遗传力，与疾病挑战后的性能和弹性测量值的遗传相关性表明，它们可能是疾病弹性的潜在遗传指标。
