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先天性长QT综合征患儿的麻醉:一例报告及文献综述

Anesthesia for a Child with Congenital Long QT Syndrome, a Case Report and Literature Review.

作者信息

Yaman Ferda, Baydogan Nurdan, Bilir Ayten, Incesulu Armagan

机构信息

Department of Anesthesiology and Reanimation, Faculty of Medicine, University of Eskişehir Osmangazi, Eskişehir, Turkey.

Department of Otolaryngology, Faculty of Medicine, University of Eskişehir Osmangazi, Eskişehir, Turkey.

出版信息

Anesth Essays Res. 2021 Jan-Mar;15(1):149-151. doi: 10.4103/aer.aer_48_21. Epub 2021 Aug 30.

DOI:10.4103/aer.aer_48_21
PMID:34667364
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8462433/
Abstract

Long QT syndrome is an inherited disorder of the heart's electrical activity that may also be associated with malignant arrhythmia and cause sudden death. In addition to this inherited condition, several commonly used anesthetic drugs can prolong the QT interval. We present here a 17-month-old male patient who underwent general anesthesia for a cochlear implant. No cardiac arrhythmia was observed in the patient, whose muscle relaxant effect was reversed using sugammadex. The application of intravenous anesthetics was preferred to maintain anesthesia for this patient and was safely applied.

摘要

长QT综合征是一种遗传性心脏电活动紊乱疾病,也可能与恶性心律失常相关并导致猝死。除了这种遗传状况外,几种常用的麻醉药物也可延长QT间期。我们在此介绍一名17个月大的男性患者,他接受了人工耳蜗植入的全身麻醉。该患者未观察到心律失常,使用舒更葡糖逆转了其肌肉松弛作用。对于该患者,优先采用静脉麻醉药维持麻醉,并安全应用。

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本文引用的文献

1
Long QT Syndrome: Genetics and Future Perspective.长QT综合征:遗传学与未来展望。
Pediatr Cardiol. 2019 Oct;40(7):1419-1430. doi: 10.1007/s00246-019-02151-x. Epub 2019 Aug 22.
2
Anesthetic Considerations for Pediatric Patients With Congenital Long QT Syndrome.先天性长QT综合征患儿的麻醉注意事项
J Cardiothorac Vasc Anesth. 2019 Jul;33(7):2030-2038. doi: 10.1053/j.jvca.2018.11.005. Epub 2018 Nov 12.
3
Safety and efficacy of propofol anesthesia for pediatric target-controlled infusion in children below 3 years of age: a retrospective observational study.异丙酚麻醉在 3 岁以下儿童靶控输注中的安全性和有效性:一项回顾性观察研究。
Expert Opin Drug Saf. 2018 Oct;17(10):983-989. doi: 10.1080/14740338.2018.1524460. Epub 2018 Sep 22.
4
Sevoflurane-associated torsade de pointes in a patient with congenital long QT syndrome genotype 2.一名先天性长QT综合征2型患者出现七氟烷相关的尖端扭转型室性心动过速。
J Clin Anesth. 2016 Sep;33:81-5. doi: 10.1016/j.jclinane.2016.03.011. Epub 2016 Apr 29.
5
The safety of modern anesthesia for children with long QT syndrome.长QT综合征患儿现代麻醉的安全性
Anesth Analg. 2014 Oct;119(4):932-938. doi: 10.1213/ANE.0000000000000389.
6
Impact of genetics on the clinical management of channelopathies.遗传学对通道病临床管理的影响。
J Am Coll Cardiol. 2013 Jul 16;62(3):169-180. doi: 10.1016/j.jacc.2013.04.044. Epub 2013 May 15.
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Prevalence of the congenital long-QT syndrome.先天性长QT综合征的患病率。
Circulation. 2009 Nov 3;120(18):1761-7. doi: 10.1161/CIRCULATIONAHA.109.863209. Epub 2009 Oct 19.
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Anesthesia for patients with congenital long QT syndrome.先天性长QT综合征患者的麻醉
Anesthesiology. 2005 Jan;102(1):204-10. doi: 10.1097/00000542-200501000-00029.
9
Risk stratification in the long-QT syndrome.长QT综合征的风险分层
N Engl J Med. 2003 May 8;348(19):1866-74. doi: 10.1056/NEJMoa022147.
10
Ventricular fibrillation related to reversal of the neuromuscular blockade in a patient with long QT syndrome.一名长QT综合征患者在神经肌肉阻滞逆转过程中发生心室颤动。
Acta Anaesthesiol Scand. 1999 Mar;43(3):352-5. doi: 10.1034/j.1399-6576.1999.430319.x.