Department of Oncology, Hematology and Bone Marrow Transplantation with Division of Pneumology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Mildred Scheel Cancer Career Center, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Leuk Lymphoma. 2022 Mar;63(3):664-671. doi: 10.1080/10428194.2021.1992626. Epub 2021 Oct 20.
The severity and mortality of COVID-19 and seasonal influenza were recently compared in the general population but not in patients with hematological malignancies. We analyzed the clinical courses of 79 patients with hematological malignancies and diagnosis of either SARS-CoV-2 ( = 29) or influenza A or B infections ( = 50) who were admitted or were already under treatment in the Department of Oncology, Hematology and Stem cell Transplantation at the University Medical Center Hamburg-Eppendorf, Germany, between 1 January 2012 and 31 January 2021. For COVID-19, we observed significantly higher rates of acute respiratory distress syndrome with 48% (14/29) compared to 14% (7/50) in the influenza group ( = 0.001) as well as a significantly higher virus-associated 90-day mortality (41% vs. 12%, = 0.005). Based on our results, we conclude that infections with SARS-CoV-2 are more severe than influenza A or B in patients with hematological malignancies.
我们分析了 2012 年 1 月 1 日至 2021 年 1 月 31 日期间在德国汉堡大学医学中心肿瘤学、血液学和干细胞移植科住院或正在接受治疗的 79 名患有血液系统恶性肿瘤且确诊为 SARS-CoV-2（ = 29）或甲型或乙型流感（ = 50）的患者的临床病程。对于 COVID-19，我们观察到急性呼吸窘迫综合征的发生率明显更高，分别为 48%（14/29）和 14%（7/50）（ = 0.001），以及病毒相关的 90 天死亡率也明显更高（分别为 41%和 12%， = 0.005）。基于我们的结果，我们得出结论，与甲型或乙型流感相比，SARS-CoV-2 感染在血液系统恶性肿瘤患者中更为严重。
