Caudle R J, Crawford A H, Gelfand M J, Gruppo R A
J Pediatr Orthop. 1987 Jan-Feb;7(1):93-5. doi: 10.1097/01241398-198701000-00019.
"Cold" lesions on bone scan have been reported in a variety of disease processes, including infection, avascular necrosis, and cysts. We present two cases of children who presented with large "cold" areas on technetium bone scans and were treated initially for septic processes. Acute childhood leukemia frequently presents with bone or joint pain, fever, and elevation of the erythrocyte sedimentation rate. Although the diagnosis may be difficult if the characteristic clinical signs and laboratory findings are absent, the presence of anemia should alert the physician to the possibility of malignancy. Bone scanning provides a sensitive method of localizing pathology, but diagnosis requires biopsy or marrow aspiration.
骨扫描上的“冷”病灶已在多种疾病过程中被报道，包括感染、缺血性坏死和囊肿。我们报告两例儿童病例，他们在锝骨扫描上出现大片“冷”区，最初因感染性疾病接受治疗。儿童急性白血病常表现为骨或关节疼痛、发热以及红细胞沉降率升高。尽管如果缺乏特征性临床体征和实验室检查结果可能难以诊断，但贫血的存在应提醒医生注意恶性肿瘤的可能性。骨扫描提供了一种定位病变的敏感方法，但诊断需要活检或骨髓穿刺。
