阻塞性睡眠呼吸暂停和总睡眠时间与接受常规多导睡眠图检查的儿童健康相关生活质量的关联：一种 PROMIS 方法。
Association of obstructive sleep apnea and total sleep time with health-related quality of life in children undergoing a routine polysomnography: a PROMIS approach.
机构信息
Otolaryngology Head and Neck Surgery, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
Rosalind Franklin University, Chicago, Illinois.
出版信息
J Clin Sleep Med. 2022 Mar 1;18(3):801-808. doi: 10.5664/jcsm.9726.
STUDY OBJECTIVES
Obstructive sleep apnea (OSA) negatively impacts health-related quality of life (HR-QoL) in adults, but few pediatric studies have explored this relationship or the relationships between HR-QoL domains.
METHODS
Patients aged 8-17 years visiting the sleep laboratory from July 2019 to January 2020 for overnight polysomnography participated in the study. Controls seen for problems other than sleep disturbance were recruited from Department of Pediatrics outpatient clinics. HR-QoL was assessed by Patient-Reported Outcome Measure Information System (PROMIS) profile questionnaires, version 2.0. Statistical analysis was conducted using R 3.6.0 (R Foundation for Statistical Computing, Vienna, Austria).
RESULTS
One hundred twenty-two patients were included in the final analysis. Sixty-four patients were males (52.4%). Twenty-nine (23.8%) had mild OSA, 8 (6.6%) had moderate OSA, 17 (13.9%) had severe OSA, 46 (37.7%) were without OSA, and 22 (18.0%) were controls. Patients referred for polysomnography had lower physical function mobility compared with controls ( = .03). Increased OSA severity was linearly associated with a decrease in physical function mobility ( = .008). Correlation analysis revealed that physical function mobility was positively associated with total sleep time ( = .02) and negatively associated with apnea-hypopnea index ( .01). Age was positively associated with fatigue ( .02) and negatively associated with deep sleep ( .001). Regression analysis revealed that physical function mobility was positively associated with total sleep time ( .02) and negatively associated with apnea-hypopnea index ( = .04) after controlling for age, sex, and number of arousals.
CONCLUSIONS
OSA and total sleep time were associated with problems with physical function mobility after adjusting for age, sex, and number of arousals.
CITATION
Xu S, Turakhia S, Miller M, et al. Association of obstructive sleep apnea and total sleep time with health-related quality of life in children undergoing a routine polysomnography: a PROMIS approach. . 2022;18(3):801-808.
研究目的
阻塞性睡眠呼吸暂停（OSA）会降低成年人的健康相关生活质量（HR-QoL），但很少有儿科研究探讨这种关系或 HR-QoL 各领域之间的关系。
方法
2019 年 7 月至 2020 年 1 月，在睡眠实验室过夜进行多导睡眠图检查的 8-17 岁患者参加了这项研究。从儿科学门诊招募了因睡眠障碍以外的问题就诊的对照组。通过患者报告结果测量信息系统（PROMIS）简表问卷评估 HR-QoL，版本 2.0。使用 R 3.6.0（维也纳，奥地利，R 基金会统计计算）进行统计分析。
结果
最终分析纳入 122 例患者。64 例为男性（52.4%）。29 例（23.8%）为轻度 OSA，8 例（6.6%）为中度 OSA，17 例（13.9%）为重度 OSA，46 例（37.7%）无 OSA，22 例（18.0%）为对照组。与对照组相比，接受多导睡眠图检查的患者移动身体功能较低（ =.03）。OSA 严重程度的增加与移动身体功能下降呈线性相关（ =.008）。相关分析显示，身体功能移动性与总睡眠时间呈正相关（ =.02），与呼吸暂停低通气指数呈负相关（ =.01）。年龄与疲劳呈正相关（ =.02），与深度睡眠呈负相关（ =.001）。回归分析显示，在控制年龄、性别和唤醒次数后，身体功能移动性与总睡眠时间呈正相关（ =.02），与呼吸暂停低通气指数呈负相关（ =.04）。
结论
在调整年龄、性别和唤醒次数后，OSA 和总睡眠时间与身体功能移动性问题相关。
引文
徐 S，图拉希亚 S，米勒 M，等。在接受常规多导睡眠图检查的儿童中，阻塞性睡眠呼吸暂停和总睡眠时间与健康相关生活质量的关系：PROMIS 方法。睡眠 2022；18（3）：801-808。
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