Department of Clinical Sciences, North Carolina State University, Raleigh, NC; Department of Veterinary Diagnostic and Production Animal Medicine, Iowa State University, Ames, IA.
Department of Clinical Sciences, North Carolina State University, Raleigh, NC.
J Equine Vet Sci. 2021 Nov;106:103727. doi: 10.1016/j.jevs.2021.103727. Epub 2021 Aug 6.
Transcervical intrauterine infusion of antibiotics may more effectively treat pathogens associated with fetal and neonatal disease in pregnant mares than standard systemic routes. The objective of this study was to assess the safety of transcervical antibiotic infusion by characterizing the gestational outcome in nine healthy pregnant pony mares following a single transcervical infusion of 2.4 million IU of procaine penicillin and 200 mg of gentamicin in a 10 mL volume during late gestation. Assessment of fetal-placental health was performed through serial measurement of the combined thickness of the uterus and placenta (CTUP) and fetal heart rate and mares and foals were closely monitored in the periparturient period. Fetal heart rate and CTUP remained unchanged after infusion, with no evidence of fluid accumulation or significant increase at the time-points 24, 48, and 72 hours. All mares foaled without complication 12-58 days after antibiotic infusion at a mean gestational age of 322.7 ± 12.7 days. Two out of nine foals displayed signs of mild neonatal maladjustment syndrome that responded to minimal supportive care and all foals survived to weaning without further complications.
经宫颈宫内输注抗生素可能比标准全身途径更有效地治疗与妊娠母马胎儿和新生儿疾病相关的病原体。本研究的目的是通过描述 9 头健康妊娠矮种马在妊娠晚期单次经宫颈输注 240 万 IU 普鲁卡因青霉素和 200mg 庆大霉素后，单个宫颈抗生素输注的妊娠结局来评估经宫颈抗生素输注的安全性。通过连续测量子宫和胎盘的总厚度（CTUP）以及胎儿心率来评估胎儿胎盘的健康状况，并在围产期密切监测母马和小马。输注后胎儿心率和 CTUP 保持不变，在 24、48 和 72 小时时没有证据表明有液体积聚或明显增加。所有母马在抗生素输注后 12-58 天平均妊娠龄为 322.7±12.7 天无并发症分娩。9 头小马中有两头出现轻度新生儿适应不良综合征的迹象，但仅接受了最低限度的支持性治疗，所有小马均存活至断奶，无进一步并发症。
