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血管内动脉瘤修复术与开放修复术相比并不能提高 80 岁以上老年人的生存率。

Endovascular Aneurysm Repair Compared With Open Repair Does Not Improve Survival in Octogenarians.

机构信息

Division of Vascular and Endovascular Surgery, Department of Surgery, Nagoya University Graduate School of Medicine.

出版信息

Circ J. 2021 Nov 25;85(12):2166-2171. doi: 10.1253/circj.CJ-21-0574. Epub 2021 Oct 21.

Abstract

BACKGROUND

Not every elderly person is frail, and whether it would be beneficial to perform endovascular aneurysm repair (EVAR) solely because a patient is older is unclear. This study aimed to compare the results of EVAR and open surgical repair (OSR) in elderly individuals.

METHODS AND RESULTS

From May 1998 to March 2021, 828 EVAR patients and 886 OSR patients with abdominal aortic aneurysm (AAA) were reviewed. Patients aged ≥80 years were included among them. After propensity score matching by age, sex, and American Society of Anesthesiologists (ASA) classification, the outcomes were compared between patients who underwent EVAR and OSR. The study cohort was composed of 351 EVAR patients and 90 OSR patients. The groups had similar comorbidities, except that EVAR patients were significantly older and had higher ASA classifications. After propensity score matching, 79 pairs of patients were selected. The 30-day mortality (0 vs. 1.2%) and aneurysm-related death (ARD) rates during follow up (2.3% vs. 2.3%, respectively) were similar between the groups. Kaplan-Meier curves revealed that estimated overall survival and freedom from ARD were also similar.

CONCLUSIONS

This study suggests that EVAR cannot improve survival outcomes compared with OSR if applied solely because a patient is aged ≥80 years. Not only age but also other risk factors and quality of life after surgery need to be further studied.

摘要

背景

并非每个老年人都是虚弱的,仅因为患者年龄较大而进行血管内动脉瘤修复(EVAR)是否有益尚不清楚。本研究旨在比较 EVAR 和开放手术修复(OSR)在老年患者中的结果。

方法和结果

1998 年 5 月至 2021 年 3 月,回顾了 828 例 EVAR 患者和 886 例 OSR 患者的腹主动脉瘤(AAA)。其中包括年龄≥80 岁的患者。通过年龄、性别和美国麻醉医师协会(ASA)分类的倾向评分匹配后,比较了接受 EVAR 和 OSR 的患者的结局。研究队列由 351 例 EVAR 患者和 90 例 OSR 患者组成。两组的合并症相似,但 EVAR 患者年龄明显更大,ASA 分级更高。进行倾向评分匹配后,选择了 79 对患者。30 天死亡率(0%与 1.2%)和随访期间的动脉瘤相关死亡率(ARD)(2.3%与 2.3%)相似。Kaplan-Meier 曲线显示,估计的总生存率和 ARD 无事件生存率也相似。

结论

如果仅因为患者年龄≥80 岁而进行 EVAR,本研究表明其并不能改善生存结果,而优于 OSR。不仅年龄,而且其他风险因素和手术后的生活质量需要进一步研究。

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