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经肺动脉血抽吸细胞学检查诊断的胃癌相关肺肿瘤血栓性微血管病。

Pulmonary Tumor Thrombotic Microangiopathy Due to Gastric Cancer Diagnosed Antemortem by a Cytological Examination of Aspirated Pulmonary Artery Blood.

机构信息

Department of Gastroenterology and Oncology, Tokushima University Hospital, Japan.

Department of Gastroenterology and Oncology, Tokushima University Graduate School of Biomedical Sciences, Japan.

出版信息

Intern Med. 2022 May 15;61(10):1491-1495. doi: 10.2169/internalmedicine.8313-21. Epub 2021 Oct 19.

DOI:10.2169/internalmedicine.8313-21
PMID:34670901
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9177363/
Abstract

A 66-year-old Japanese man receiving systemic chemotherapy for advanced gastric cancer presented with exertional dyspnea. D-dimer was elevated in the blood. Echocardiography revealed pulmonary hypertension, and a ventilation-perfusion scan indicated decreased perfusion in the bilateral lungs. Cardiac catheterization showed no evidence of pulmonary artery embolization and revealed cytologically confirmed adenocarcinoma. Thus, pulmonary tumor thrombotic microangiopathy (PTTM) was diagnosed. The patient died of respiratory failure on the 17th hospitalization day despite systemic chemotherapy. Retrospective serological testing revealed increased vascular endothelial growth factor in the pulmonary artery blood. This is a rare case with antemortem cytologically proven PTTM mediated by VEGF.

摘要

一位 66 岁的日本男性因晚期胃癌正在接受全身化疗，出现劳力性呼吸困难。血液中 D-二聚体升高。超声心动图显示肺动脉高压，通气灌注扫描显示双肺灌注减少。心导管检查未发现肺动脉栓塞的证据，并发现细胞学证实的腺癌。因此，诊断为肺肿瘤血栓性微血管病（PTTM）。尽管进行了全身化疗，患者仍在第 17 次住院当天因呼吸衰竭死亡。回顾性血清学检测显示肺动脉血液中血管内皮生长因子升高。这是一例罕见的病例，生前通过 VEGF 介导的细胞病理学证实为 PTTM。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0548/9177363/1aa0fc3135ab/1349-7235-61-1491-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0548/9177363/217be893b234/1349-7235-61-1491-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0548/9177363/86a501ea658d/1349-7235-61-1491-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0548/9177363/203835c9b682/1349-7235-61-1491-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0548/9177363/5c61c85a4f7f/1349-7235-61-1491-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0548/9177363/1aa0fc3135ab/1349-7235-61-1491-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0548/9177363/217be893b234/1349-7235-61-1491-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0548/9177363/86a501ea658d/1349-7235-61-1491-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0548/9177363/203835c9b682/1349-7235-61-1491-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0548/9177363/5c61c85a4f7f/1349-7235-61-1491-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0548/9177363/1aa0fc3135ab/1349-7235-61-1491-g005.jpg

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本文引用的文献

1
The Molecular Mechanisms of Cardiotoxicity Induced by HER2, VEGF, and Tyrosine Kinase Inhibitors: an Updated Review.曲妥珠单抗、VEGF 和酪氨酸激酶抑制剂诱导心脏毒性的分子机制：最新综述。
Cardiovasc Drugs Ther. 2022 Jun;36(3):511-524. doi: 10.1007/s10557-021-07181-3. Epub 2021 Apr 13.
2
Successful antemortem diagnosis and treatment of pulmonary tumor thrombotic microangiopathy.肺肿瘤血栓性微血管病的生前成功诊断与治疗。
Intern Med. 2014;53(22):2595-9. doi: 10.2169/internalmedicine.53.2379. Epub 2014 Nov 15.
3
Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial.
免疫化疗治疗晚期非小细胞肺癌后出现肺部肿瘤血栓性微血管病：病例报告。
BMC Pulm Med. 2023 Apr 17;23(1):124. doi: 10.1186/s12890-023-02419-2.
4
Echocardiographic Assessment of Patients with Pulmonary Tumor Thrombotic Microangiopathy First Diagnosed in the Emergency Department.急诊科首次诊断的肺肿瘤血栓性微血管病患者的超声心动图评估
Diagnostics (Basel). 2022 Jan 20;12(2):259. doi: 10.3390/diagnostics12020259.
雷莫芦单抗联合紫杉醇对比安慰剂联合紫杉醇治疗既往治疗的晚期胃或胃食管结合部腺癌患者（RAINBOW）：一项双盲、随机、III 期临床试验。
Lancet Oncol. 2014 Oct;15(11):1224-35. doi: 10.1016/S1470-2045(14)70420-6. Epub 2014 Sep 17.
4
Pulmonary tumor thrombotic microangiopathy: a clinical analysis of 30 autopsy cases.肺肿瘤血栓性微血管病：30例尸检病例的临床分析
Intern Med. 2013;52(12):1317-23. doi: 10.2169/internalmedicine.52.9472.
5
Platelet-derived growth factor-A and vascular endothelial growth factor-C contribute to the development of pulmonary tumor thrombotic microangiopathy in gastric cancer.血小板衍生生长因子-A 和血管内皮生长因子-C 有助于胃癌肺肿瘤血栓性微血管病的发展。
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6
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7
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8
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10
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J Clin Pathol. 2010 Apr;63(4):367-9. doi: 10.1136/jcp.2010.075739.