Fukiage Yusuke, Kabuto Takafumi, Yokokawa Ryusei, Kurosawa Manabu
Department of Urology, Nagahama City Hospital.
Department of Pathology, Nagahama City Hospital.
Nihon Hinyokika Gakkai Zasshi. 2020;111(4):154-158. doi: 10.5980/jpnjurol.111.154.
Mucin-producing urothelial-type adenocarcinoma of the prostate (MPUAP) is a very rare disease. MPUAP has been reported to progress faster than the rate at which normal prostate cancer progresses. We report a case of MPUAP with long-term survival. The patient was a 65-year-old man. Computed tomography and magnetic resonance imaging showed a cystic lesion extending from the prostate to the urethra. We performed transrectal prostate biopsy and transurethral resection of the tumor, and the pathological diagnosis was adenocarcinoma. Subsequently, we performed total cystectomy, ureterostomy, and pelvic lymphadenectomy. Based on the pathological and immunostaining findings (prostate-specific antigen negativity, CDX-2 positivity, cytokeratin 20 positivity, 34β-E12 positivity), the patient was diagnosed with MPUAP. Four years after the surgery, recurrence or metastasis was not observed.
前列腺黏液产生性尿路上皮型腺癌(MPUAP)是一种非常罕见的疾病。据报道,MPUAP的进展速度比正常前列腺癌的进展速度更快。我们报告一例MPUAP患者长期存活的病例。该患者为一名65岁男性。计算机断层扫描和磁共振成像显示一个从前列腺延伸至尿道的囊性病变。我们进行了经直肠前列腺活检和经尿道肿瘤切除术,病理诊断为腺癌。随后,我们进行了全膀胱切除术、输尿管造口术和盆腔淋巴结清扫术。根据病理和免疫染色结果(前列腺特异性抗原阴性、CDX-2阳性、细胞角蛋白20阳性、34β-E12阳性),该患者被诊断为MPUAP。手术后四年,未观察到复发或转移。