Department of Oral Medicine and Radiology, Malla Reddy Institute of Dental Sciences, Hyderabad, India.
Private Practitioner, Hyderabad, India.
Minerva Dent Oral Sci. 2022 Jun;71(3):125-130. doi: 10.23736/S2724-6329.21.04578-2. Epub 2021 Oct 21.
Up to one third (3-33%) oral squamous cell carcinomas develop from potentially malignant lesions. Most common potentially malignant lesions (PML) are leukoplakia and lichen planus. It is very important to diagnose PML at early stage to prevent malignant transformation of lesion. Survivin is a smallest member of the inhibitor of apoptosis (IAP) family of proteins. Survivin plays an important role in apoptosis regulation. High expression of survivin is an early event during oral carcinogenesis and it acts as a tool for the identification of precancerous lesions at higher risk of progression into invasive carcinoma. The aim of the study was to evaluate the expression of survivin in oral leukoplakia, oral lichen planus.
Fifteen patients with oral lichen planus and 15 patients with oral leukoplakia were selected as subjects for the present study and 15 patients with normal oral mucosa were selected as controls and were evaluated for expression of survivin. All sections were H&E stained and were studied immunohistochemically for the expression of survivin.
Expression of survivin was evaluated based on the percentage of cells expressing surviving, as well as grading. Significant survivin expression was detected in oral leukoplakia and oral lichen planus (P<0.001).
Expression of survivin in potentially malignant lesions indicates the potential risk of malignant transformation.
多达三分之一（3-33%）的口腔鳞状细胞癌源自潜在恶性病变。最常见的潜在恶性病变（PML）是白斑和扁平苔藓。早期诊断 PML 对于防止病变恶性转化非常重要。生存素是凋亡抑制蛋白（IAP）家族蛋白中最小的成员。生存素在细胞凋亡调控中发挥重要作用。生存素的高表达是口腔癌发生过程中的早期事件，它可作为识别具有更高进展为浸润性癌风险的癌前病变的工具。本研究旨在评估生存素在口腔白斑、口腔扁平苔藓中的表达。
选择 15 例口腔扁平苔藓患者和 15 例口腔白斑患者作为研究对象，选择 15 例口腔正常黏膜患者作为对照，并评估生存素的表达。所有切片均进行 H&E 染色，并进行免疫组织化学检测生存素的表达。
根据表达生存素的细胞百分比以及分级来评估生存素的表达。在口腔白斑和口腔扁平苔藓中检测到显著的生存素表达（P<0.001）。
潜在恶性病变中生存素的表达表明存在恶性转化的潜在风险。
