神经生长因子调节成熟感觉神经元的动作电位持续时间。
Nerve growth factor regulates the action potential duration of mature sensory neurons.
作者信息
Chalazonitis A, Peterson E R, Crain S M
出版信息
Proc Natl Acad Sci U S A. 1987 Jan;84(1):289-93. doi: 10.1073/pnas.84.1.289.
Abstract
The effect of nerve growth factor (NGF) on the action potential of sensory ganglion neurons was investigated in long-term organotypic cultures of embryonic mouse dorsal root ganglia grown isolated or attached to spinal cord explants. The present study demonstrates that NGF regulates a specific bioelectric property of these neurons--the duration of the Ca2+ component of the somatic action potential--at mature stages when they no longer require NGF for survival. Prolonged culture of fetal mouse dorsal root ganglion neurons with relatively low levels of NGF shortens the duration of the action potential. Furthermore, addition or withdrawal of NGF in mature cultures results, within several days, in shorter or longer action potential durations, respectively. Exposure to anti-NGF antiserum accelerates the onset of the longer-lasting action potentials elicited by simple withdrawal of NGF. This plastic response of sensory neurons to NGF may be important in regulating their physiological properties and/or their response to injury.
摘要
在分离培养或与脊髓外植体相连培养的胚胎小鼠背根神经节长期器官型培养物中，研究了神经生长因子（NGF）对感觉神经节神经元动作电位的影响。本研究表明，在成熟阶段，当这些神经元不再需要NGF来维持生存时，NGF可调节它们的一种特定生物电特性——躯体动作电位Ca2+成分的持续时间。用相对低水平的NGF对胎鼠背根神经节神经元进行长时间培养会缩短动作电位的持续时间。此外，在成熟培养物中添加或去除NGF，分别会在数天内导致动作电位持续时间缩短或延长。暴露于抗NGF抗血清会加速因简单去除NGF而引发的持续时间更长的动作电位的起始。感觉神经元对NGF的这种可塑性反应可能在调节其生理特性和/或其对损伤的反应中起重要作用。
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