未用药的精神分裂症患者左侧苍白球异常。
Left globus pallidus abnormality in never-medicated patients with schizophrenia.
作者信息
Early T S, Reiman E M, Raichle M E, Spitznagel E L
出版信息
Proc Natl Acad Sci U S A. 1987 Jan;84(2):561-3. doi: 10.1073/pnas.84.2.561.
Abstract
Schizophrenia is a severe psychiatric disorder characterized by onset in young adulthood, the occurrence of hallucinations and delusions, and the development of enduring psychosocial disability. The pathophysiology of this disorder remains unknown. Studies of cerebral blood flow and metabolism designed to identify brain abnormalities in schizophrenia have been limited by inadequate methods of anatomical localization and the possibility of persistent medication effects. We have now used positron emission tomography and a validated method of anatomical localization in an attempt to identify abnormalities of regional cerebral blood flow in newly diagnosed never-medicated patients with schizophrenia. An exploratory study of 5 patients and 10 normal control subjects identified abnormally high blood flow in the left globus pallidus of patients with schizophrenia. A replication study of 5 additional patients and 10 additional control subjects confirmed this finding. No other abnormalities were found.
摘要
精神分裂症是一种严重的精神障碍，其特征为在成年早期发病、出现幻觉和妄想以及发展为持久的社会心理功能障碍。这种疾病的病理生理学仍然未知。旨在识别精神分裂症患者脑异常的脑血流和代谢研究受到解剖定位方法不足以及持续药物作用可能性的限制。我们现在使用正电子发射断层扫描和一种经过验证的解剖定位方法，试图识别新诊断的未用药精神分裂症患者的局部脑血流异常。一项对5名患者和10名正常对照受试者的探索性研究发现，精神分裂症患者左侧苍白球血流异常高。对另外5名患者和10名对照受试者的重复研究证实了这一发现。未发现其他异常。
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