From the Department of Pathology, Yale University School of Medicine, New Haven, Connecticut (Wang, Gilani, Cai).
The Department of Laboratory Medicine & Pathology, University of Washington, Seattle (Xu).
Arch Pathol Lab Med. 2021 Nov 1;145(11):1379-1386. doi: 10.5858/arpa.2021-0093-RA.
CONTEXT.—: Salivary gland-type tumors (SGTs) of the lung represent a distinct group of lung neoplasms. Pulmonary SGTs often pose diagnostic challenges, especially in small biopsy and cytology samples because of limited sample volume and overlapping morphology among pulmonary SGTs, metastatic SGTs of head and neck origin, and other lung tumors.
OBJECTIVE.—: To identify the clinical characteristics, histomorphology, immunophenotypic features, and molecular alterations that are crucial for the diagnosis and differential diagnosis of pulmonary SGTs, especially in small biopsy and cytology specimens.
DATA SOURCES.—: Literature review and authors' personal practice experience.
CONCLUSIONS.—: An accurate diagnosis of pulmonary SGTs can be achieved by careful evaluation of clinical findings and histomorphology in conjunction with immunohistochemical studies and molecular analysis.
肺涎腺型肿瘤（SGTs）是一组独特的肺部肿瘤。由于肺 SGTs 的样本量有限，并且与肺 SGTs、头颈部转移性 SGTs 和其他肺部肿瘤的形态学存在重叠，因此肺 SGTs 的诊断极具挑战性，尤其是在小活检和细胞学样本中。
确定对于肺 SGTs 的诊断和鉴别诊断至关重要的临床特征、组织形态学、免疫表型特征和分子改变，尤其是在小活检和细胞学标本中。
文献复习和作者的个人实践经验。
通过仔细评估临床发现和组织形态学，并结合免疫组织化学研究和分子分析，可以准确诊断肺 SGTs。
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