Department of Pathology, All India Institute of Medical Sciences, New Delhi, 110029, India.
Department of Pathology, All India Institute of Medical Sciences, New Delhi, 110029, India.
Surg Pathol Clin. 2024 Jun;17(2):227-241. doi: 10.1016/j.path.2023.11.001. Epub 2023 Dec 26.
Pulmonary salivary gland-type, although bear resemblance to their salivary gland counterparts, present a diagnostic challenge due to their rarity. Clinical features overlap with lung carcinoma; however, management strategies and outcomes are distinct. Onus falls on the pathologist to avoid misinterpretation of small biopsies especially in young, nonsmokers with slow growing or circumscribed endobronchial growths. A combination of cytokeratin, myoepithelial immunohistochemical markers, and identification of signature molecular alteration is invaluable in differentiation from lung cancers and subtyping the pulmonary salivary gland-type tumor.
肺涎腺型肿瘤,尽管与涎腺肿瘤相似,但由于其罕见性,仍具有诊断挑战性。其临床表现与肺癌重叠,但管理策略和预后截然不同。病理学家有责任避免对小活检标本的错误解读,特别是在年轻、不吸烟、生长缓慢或局限于支气管内的患者中。细胞角蛋白、肌上皮免疫组化标志物的联合应用,以及鉴定特征性分子改变,对于与肺癌的鉴别和肺涎腺型肿瘤的亚型分类非常有价值。