Gordeeff A, Mercier J, Bedhet N, Delaire J
Rev Stomatol Chir Maxillofac. 1986;87(5):320-6.
As reported by Gorlin, Pindborg and Cohen, hemifacial hypertrophy is not an affection sui generis, but one that presents different aspects and is of varied etiology. The presence of a tumor must be excluded initially. The hemifacial lesion may be congenital, and form part of a diffuse affection involving the whole of one side of body including hard and soft tissues such as the tongue. Because of their role in cephalic organogenesis, an alteration in cells of neural crests appears to be at the origin of this form but the authors consider that the initial lesion develops at a much earlier stage. The lesion may be tissue-orientated: nervous as in the case of Recklinghausen's neurofibromatosis; vascular as in diffuse angiodysplasias such as the Klippel-Trenaunay-Weber syndrome. Here again the tongue participates in the expression of the disease. Finally, hemifacial hypertrophy may be secondary to a bone lesion as found in more or less diffuse fibrous osteopathies or possibly hypercondylar disorders, the absence of a tongue lesion being a diagnostic factor.
正如戈林、平德伯格和科恩所报道的，半侧颜面肥大并非一种独特的病症，而是一种呈现出不同方面且病因多样的病症。必须首先排除肿瘤的存在。半侧颜面病变可能是先天性的，并且是涉及身体一侧整个部位（包括诸如舌头等软硬组织）的弥漫性病症的一部分。由于神经嵴细胞在头部器官发生中的作用，神经嵴细胞的改变似乎是这种病症的起源，但作者认为初始病变在更早阶段就已形成。病变可能以组织为导向：如在雷克林豪森神经纤维瘤病中那样为神经组织性的；如在诸如克-特-韦综合征等弥漫性血管发育异常中那样为血管性的。在此情况下舌头同样参与了疾病的表现。最后，半侧颜面肥大可能继发于或多或少弥漫性纤维性骨病或可能的髁突过度增生等骨病变，舌头无病变是一个诊断因素。
