Selvi Öztorun Hande, Çınar Esat, Turgut Tuğba, Mut Sürmeli Deniz, Bahşi Remzi, Atmış Volkan, Varlı Murat, Aras Sevgi
Department of Geriatric Medicine, İbn-i Sina Hospital, Ankara University School of Medicine, Ankara, Turkey.
Eur Geriatr Med. 2018 Aug;9(4):493-500. doi: 10.1007/s41999-018-0065-z. Epub 2018 May 9.
Iron deficiency in older people is common and affects physical and cognitive performance. The effects of iron deficiency on nutrition and cognitive status are well established. However, there are few studies demonstrating the impact of iron deficiency treatment on functional and cognitive outcomes in the geriatric population. The aim of this study was to determine whether iron replacement treatment was associated with an improvement in the nutritional, cognitive, and functional status of older patients with iron deficiency (ID) and iron deficiency anemia (IDA).
Geriatric patients with iron deficiency and iron deficiency anemia presenting to the geriatric clinic were included in the study. Comprehensive geriatric assessment (CGA) and blood samples to investigate iron deficiency were performed at baseline and 6 month later. 81 patients were included in the study and were evaluated at follow-up in the 6th month. The CGA included the following tests: the Katz Index of Independence in Activities of Daily Living Scale (Katz ADL), the Lawton-Brody Instrumental Activities of Daily Living Scale (IADL), the Mini-Mental State Examination (MMSE), and the Mini Nutritional Assessment Short-Form (MNA-SF), as well as the assessments of hand grip strength and walking speed.
Of the 81 participating patients, 69.1% were women and 30.9% were men. The mean age was 76.8 ± 7.28 years. Follow-up after iron supplementation treatment was performed with a mean of 6.23 ± 1.58 months. Improvements occurred in the following geriatric and laboratory assessments: Lawton-Brody (IADL), MNA-SF, MMSE, hand grip strength, and walking speed evaluations and the levels of hemoglobin, iron, total iron-binding capacity, transferrin saturation, and ferritin.
It was shown that iron replacement treatment has a positive impact on functional and cognitive status and nutritional parameters in older patients with ID and IDA.
老年人缺铁情况常见，会影响身体和认知表现。缺铁对营养和认知状态的影响已得到充分证实。然而，鲜有研究表明缺铁治疗对老年人群功能和认知结局的影响。本研究的目的是确定铁补充治疗是否与缺铁（ID）和缺铁性贫血（IDA）老年患者的营养、认知和功能状态改善相关。
本研究纳入了到老年门诊就诊的缺铁和缺铁性贫血老年患者。在基线和6个月后进行了全面老年评估（CGA）和用于调查缺铁情况的血样采集。81名患者纳入研究并在第6个月随访时接受评估。CGA包括以下测试：日常生活活动能力的Katz独立指数量表（Katz ADL）、洛顿 - 布罗迪日常生活活动能力量表（IADL）、简易精神状态检查表（MMSE）、微型营养评定简表（MNA - SF），以及握力和步行速度评估。
81名参与患者中，69.1%为女性，30.9%为男性。平均年龄为76.8 ± 7.28岁。铁补充治疗后的随访平均时间为6.23 ± 1.58个月。在以下老年评估和实验室评估中出现了改善：洛顿 - 布罗迪（IADL）、MNA - SF、MMSE、握力和步行速度评估，以及血红蛋白、铁、总铁结合力、转铁蛋白饱和度和铁蛋白水平。
结果表明，铁补充治疗对ID和IDA老年患者的功能和认知状态以及营养参数有积极影响。
