Steinbeck Peninsula Equine Clinics, 100 Ansel Lane, Menlo Park, CA 94028, USA.
Vet Clin North Am Equine Pract. 2021 Dec;37(3):619-638. doi: 10.1016/j.cveq.2021.08.001. Epub 2021 Oct 19.
Endocrinopathic laminitis (EL) primarily occurs because of insulin dysregulation (ID) mediated through downstream effects of insulin on IGF-1R in lamellar tissues. There is likely contributing vascular and metabolic dysfunction within the lamellae, but EL is relatively non-inflammatory. EL is associated with lamellar stretching, proliferation, and failure, ultimately causing failure of the suspensory apparatus of the distal phalanx. Proper education regarding mitigating risk factors makes this a largely preventable cause of laminitis. Annual hoof evaluation plus screening geriatric horses for pituitary pars intermedia dysfunction and ID, and younger horses for ID, can significantly decrease the incidence of this devastating condition.
内分泌性蹄叶炎（EL）主要是由于胰岛素失调（ID）引起的，这种失调通过胰岛素对蹄叶组织中 IGF-1R 的下游作用介导。在蹄叶中可能存在血管和代谢功能障碍，但 EL 相对非炎症性。EL 与蹄叶伸展、增殖和衰竭有关，最终导致远指（趾）骨悬韧带装置的衰竭。关于减轻风险因素的正确教育使得这一主要可预防的蹄叶炎病因。每年的蹄评估加上对老年马的垂体中叶功能障碍和 ID 以及年轻马的 ID 筛查，可以显著降低这种破坏性疾病的发生率。
