Getu Ayechew Adera, Abuhay Deribew Abebaw, Goshu Bahiru Tenaw
Department of Physiology, College of Medicine and Health Sciences, University of Gondar, Gondar, Amhara, Ethiopia.
Department of Physiology, College of Medicine and Health Sciences, Debre Tabor University, Debre Tabor, Amhara, Ethiopia.
Integr Blood Press Control. 2021 Oct 5;14:133-139. doi: 10.2147/IBPC.S331467. eCollection 2021.
Orthostatic hypotension (OH) is defined as a fall in systolic blood pressure (SBP) ≥20 mmHg or diastolic BP (DBP) ≥10 mmHg within 3 minutes of standing. OH incidence is increased with hypertension, and management of these patients may pose challenges, as treatment of one can worsen the other.
This study aimed to determine the prevalence of OH and its associated factors among male hypertensive patients at the University of Gondar Comprehensive Specialized Hospital, Gondar, Ethiopia.
A hospital-based cross-sectional design was employed. Seated BP was measured twice and the average of the two taken. After BP had been stabilized for 5 minutes, SBP within 3 minutes of standing was measured twice and the minimum of the two taken. A drop of ≥20 mmHg in SBP within 3 minutes of standing was taken as OH. All male hypertensive patients who were able to attain a standing position were included. Sociodemographic, anthropometric, and clinical status of the patients were taken using structured interviewer-administered questionnaires. Data were entered and analyzed using SPSS 21. Both bivariate and multivariate logistic regression analysis were done. P≤0.05 was considered statistically significant.
The median age of study participants was 57 (25-96) years. The prevalence of OH was 17.6%. Uncontrolled hypertension (adjusted OR 2.08, 95% CI 1.125-3.872) and duration of hypertension ≥5 years (adjusted OR 2.04, 95% CI 1.069-3.895) were significantly associated with OH in hypertensive patients.
The prevalence of OH among male hypertensive patients was high. Hypertensive patients whose BP was uncontrolled and having had hypertension ≥5 years were risk factors of OH.
直立性低血压（OH）定义为站立3分钟内收缩压（SBP）下降≥20 mmHg或舒张压（DBP）下降≥10 mmHg。OH的发生率随高血压而增加，这些患者的管理可能具有挑战性，因为治疗其中一种疾病可能会使另一种疾病恶化。
本研究旨在确定埃塞俄比亚贡德尔大学贡德尔综合专科医院男性高血压患者中OH的患病率及其相关因素。
采用基于医院的横断面设计。坐位血压测量两次并取平均值。血压稳定5分钟后，站立3分钟内的SBP测量两次并取最小值。站立3分钟内SBP下降≥20 mmHg被视为OH。纳入所有能够站立的男性高血压患者。使用结构化访谈问卷收集患者的社会人口统计学、人体测量学和临床状况数据。数据使用SPSS 21录入和分析。进行了双变量和多变量逻辑回归分析。P≤0.05被认为具有统计学意义。
研究参与者的中位年龄为57（25 - 96）岁。OH的患病率为17.6%。高血压未得到控制（调整后的OR为2.08，95% CI为1.125 - 3.872）和高血压病程≥5年（调整后的OR为2.04，95% CI为1.069 - 3.895）与高血压患者的OH显著相关。
男性高血压患者中OH的患病率较高。血压未得到控制且高血压病程≥5年的高血压患者是OH的危险因素。
