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合成生物学论坛:用新技术迎接巨大挑战。

A forum on synthetic biology: meet the great challenges with new technology.

作者信息

Zhao Weijie

机构信息

NSR news editor based in Beijing.

出版信息

Natl Sci Rev. 2020 Oct 17;8(1):nwaa252. doi: 10.1093/nsr/nwaa252. eCollection 2021 Jan.

DOI:10.1093/nsr/nwaa252
PMID:34676090
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7665648/
Abstract

Synthetic biology aims to redesign and reconstruct living systems for understanding life or for useful real-world applications. In the past two decades, scientists have been able to use engineered living systems to produce many kinds of products from bioplastics to drugs, to construct a minimal bacterium with a fully synthetic genome and to store huge amount of information within a cell. And in 2020, when the COVID-19 pandemic swept across the world, the synthetic biology community became one of the major forces to develop effective diagnostic approaches as well as the drugs and vaccines, to rapidly cope with this great challenge with the state-of-the-art technologies in their hands. In this panel discussion held on 3rd August 2020, eleven pioneering synthetic biologists from six countries across four continents gathered to discuss the development trend, challenges and biosafety issues concerning synthetic biology. Professor of Genetics at Harvard Medical School and Professor of Health Sciences and Technology at Harvard and MIT, USA Professor of Structural Biology in the Department of Infectious Disease at Imperial College and a member of the Science Advisory Board of Tierra Biosciences, UK Professor in School of Science, Technology and Innovation, and Department of Chemical Science and Engineering at Kobe University, Japan Professor of Bioengineering and of Chemical Engineering at Stanford University and CEO of Antheia Inc., USA Professor at the Institute of Biophysics, Chinese Academy of Sciences, China Professor and Director of Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, China Termeer Professor of Medical Engineering & Science and Professor of Biological Engineering at MIT, USA Professor of Chemical Engineering and Bioengineering at the University of California, Berkeley, USA Dean of KAIST Institutes and Distinguished Professor in the Department of Chemical and Biomolecular Engineering at Korea Advanced Institute of Science and Technology (KAIST), South Korea Director of the Future Science Platform in Synthetic Biology at Commonwealth Science and Industry Research Organization (CSIRO), Australia Professor at the Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China.

摘要

合成生物学旨在重新设计和构建生命系统,以理解生命或用于实际的有益应用。在过去二十年中,科学家们已能够利用工程化生命系统生产从生物塑料到药物等多种产品,构建具有完全合成基因组的最小细菌,并在细胞内存储大量信息。2020年,当新冠疫情席卷全球时,合成生物学界成为开发有效诊断方法以及药物和疫苗的主要力量之一,凭借手中的先进技术迅速应对这一巨大挑战。在2020年8月3日举行的本次小组讨论中,来自四大洲六个国家的十一位合成生物学先驱齐聚一堂,讨论合成生物学的发展趋势、挑战和生物安全问题。美国哈佛医学院遗传学教授及哈佛和麻省理工学院健康科学与技术教授;英国帝国理工学院传染病系结构生物学教授及Tierra Biosciences科学顾问委员会成员;日本神户大学科学、技术与创新学院及化学科学与工程系教授;美国斯坦福大学生物工程与化学工程教授及Antheia公司首席执行官;中国科学院生物物理研究所教授;中国科学院深圳先进技术研究院深圳合成生物学研究所教授兼所长;美国麻省理工学院特米尔医学工程与科学教授及生物工程教授;美国加利福尼亚大学伯克利分校化学工程与生物工程教授;韩国科学技术院(KAIST)KAIST研究所所长兼化学与生物分子工程系杰出教授;澳大利亚联邦科学与工业研究组织(CSIRO)合成生物学未来科学平台主任;中国科学院上海生命科学研究院植物生理生态研究所教授。