Vyhlidal Margaret J, Adesida Adetola B
Divisions of Orthopedic Surgery and Surgical Research, Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.
Division of Otolaryngology, Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.
J Cell Physiol. 2022 Feb;237(2):1171-1181. doi: 10.1002/jcp.30616. Epub 2021 Oct 21.
Meniscus fibrochondrocytes (MFCs) are an important cell population responsible for regulating the biomechanical properties of the knee meniscus. Despite their significance, not much is known about them, including how they sense and respond to mechanical stimuli. Due to the mechanical nature of the knee joint, it is therefore paramount to our understanding of the meniscus that its mechanotransductive mechanism be elucidated. In this review, we will summarize the current knowledge on mechanotransduction in MFCs and highlight the relevance of caveolae in lieu of a recent discovery. Additionally, we will discuss the importance of future studies in this area to help advance the field of meniscus research.
半月板纤维软骨细胞（MFCs）是负责调节膝关节半月板生物力学特性的重要细胞群体。尽管它们很重要，但我们对它们的了解并不多，包括它们如何感知和响应机械刺激。由于膝关节的力学性质，因此阐明其机械转导机制对于我们理解半月板至关重要。在这篇综述中，我们将总结目前关于MFCs机械转导的知识，并根据最近的一项发现强调小窝的相关性。此外，我们将讨论该领域未来研究的重要性，以帮助推动半月板研究领域的发展。
