Research Group in Physiology, Postgraduate Program in Integral Attention to Health, Department of Life Sciences, Regional University of Northwestern State's Rio Grande do Sul (UNIJUI), Rua do Comercio, 3000 - Bairro Universitario -, Ijuí, RS, 98700-000, Brazil.
Postgraduation Program in Integral Attention to Health (PPGAIS-UNIJUI/UNICRUZ), Ijuí, RS, Brazil.
Cell Stress Chaperones. 2021 Nov;26(6):889-915. doi: 10.1007/s12192-021-01241-1. Epub 2021 Oct 22.
Physical exercise has acute and chronic effects on inflammatory balance, metabolic regulation, and redox status. Exercise-induced adaptations are mediated by enhanced 70-kDa heat shock protein (HSP70) levels and an improved heat shock response (HSR). Therefore, exercise could be useful against disease conditions [obesity, diabetes mellitus (DM), and exposure to atmospheric pollutants] marked by an impaired HSR. However, exercise performed by obese or diabetic subjects under pollution conditions might also be dangerous at certain intensities. Intensity correlates with an increase in HSP70 levels during physical exercise until a critical point at which the effort becomes harmful and impairs the HSR. Establishing a unique biomarker able to indicate the exercise intensity on metabolism and cellular fatigue is essential to ensure adequate and safe exercise recommendations for individuals with obesity or DM who require exercise to improve their metabolic status and live in polluted regions. In this review, we examined the available evidence supporting our hypothesis that HSP70 could serve as a biomarker for determining the optimal exercise intensity for subjects with obesity or diabetes when exposed to air pollution and establishing the fine threshold between anti-inflammatory and pro-inflammatory exercise effects.
体育锻炼对炎症平衡、代谢调节和氧化还原状态具有急性和慢性影响。运动引起的适应性变化是通过增强 70kDa 热休克蛋白（HSP70）水平和改善热休克反应（HSR）来介导的。因此，运动对于因 HSR 受损而导致的疾病状态（肥胖、糖尿病（DM）和暴露于大气污染物）可能是有用的。然而，肥胖或糖尿病患者在污染条件下进行运动也可能在某些强度下是危险的。强度与运动过程中 HSP70 水平的增加相关，直到达到一个临界点，此时努力变得有害并损害 HSR。建立一个能够指示代谢和细胞疲劳的运动强度的独特生物标志物对于确保肥胖或 DM 患者获得足够和安全的运动建议是至关重要的，这些患者需要运动来改善他们的代谢状态，并生活在污染地区。在这篇综述中，我们检查了现有的证据，支持我们的假设，即 HSP70 可以作为肥胖或糖尿病患者在暴露于空气污染时确定最佳运动强度的生物标志物，并确定抗炎和促炎运动效果之间的精细阈值。
