Public Health and Preventive Medicine Teaching and Research Center, Henan University of Chinese Medicine, Jinshui East Road 156, Zhengzhou, 450046, Henan, China.
Department of Medical Services, Zhengzhou Central Hospital Affiliated To Zhengzhou University, Zhengzhou, 450001, Henan, China.
Obes Surg. 2022 Jan;32(1):103-114. doi: 10.1007/s11695-021-05740-z. Epub 2021 Oct 22.
The aim of this meta-analysis is to evaluate the changes in nutritional indicators in individuals with obesity before and after SG.
A systematic retrieval of the available literature was performed using PubMed, Embase, Web of Science, and Chinese National Knowledge Infrastructure databases. The following indicators were evaluated: serum 25-hydroxyvitamin D [25(OH)D], calcium, phosphorus, iron, vitamin B12, folate, magnesium, and zinc from pre-operation to post-operation.
A total of 38 studies met inclusion criteria. A significant increase was observed in serum 25(OH)D (SMD = 0.70, 95%CI 0.38 to 1.02, P < 0.001), phosphorus (SMD = 0.40, 95%CI 0.14 to 0.67, P = 0.003), iron (SMD = 0.50, 95%CI 0.38 to 0.62, P < 0.001), and folate (SMD = 0.37, 95%CI 0.09 to 0.65, P = 0.01) after SG. Nevertheless, the increasing trend of serum phosphorus (P = 0.143) and folate (P = 0.774) disappeared in the unprescribed subgroup. A significant decrease in serum zinc (SMD = - 0.41, 95%CI - 0.81 to - 0.01, P = 0.044) was found after SG. No significant changes in serum calcium (SMD = 0.08, 95%CI - 0.09 to 0.25, P = 0.372), vitamin B12 (SMD = 0.10, 95%CI - 0.13 to 0.33, P = 0.398), and magnesium (SMD = 0.24, 95%CI - 0.10 to 0.58, P = 0.169) were observed. However, a significant decrease in serum calcium (P = 0.042) and vitamin B12 (P = 0.037) was found in the unprescribed subgroup.
Serum 25(OH)D, phosphorus, iron, and folate levels improved after a careful monitoring and due to a rigorous supplementation. The optimal dose of calcium, magnesium, and zinc supplementation has yet to be established; therefore, a broader supplementation of trace elements and minerals has to be suggested.
本荟萃分析旨在评估 SG 前后肥胖个体的营养指标变化。
使用 PubMed、Embase、Web of Science 和中国知网数据库对现有文献进行系统检索。评估指标包括术前至术后血清 25-羟维生素 D [25(OH)D]、钙、磷、铁、维生素 B12、叶酸、镁和锌。
共纳入 38 项研究。结果显示，血清 25(OH)D（SMD=0.70，95%CI 0.38 至 1.02，P<0.001）、磷（SMD=0.40，95%CI 0.14 至 0.67，P=0.003）、铁（SMD=0.50，95%CI 0.38 至 0.62，P<0.001）和叶酸（SMD=0.37，95%CI 0.09 至 0.65，P=0.01）水平显著升高。然而，在未规定亚组中，血清磷（P=0.143）和叶酸（P=0.774）的升高趋势消失。SG 后血清锌（SMD=-0.41，95%CI-0.81 至-0.01，P=0.044）显著降低。SG 后血清钙（SMD=0.08，95%CI-0.09 至 0.25，P=0.372）、维生素 B12（SMD=0.10，95%CI-0.13 至 0.33，P=0.398）和镁（SMD=0.24，95%CI-0.10 至 0.58，P=0.169）无显著变化。然而，在未规定亚组中，血清钙（P=0.042）和维生素 B12（P=0.037）显著降低。
在进行了仔细的监测和严格的补充后，血清 25(OH)D、磷、铁和叶酸水平得到了改善。钙、镁和锌的最佳补充剂量尚未确定；因此，必须建议更广泛地补充微量元素和矿物质。
