Du Le, Zahra Aqeela, Jia Meng, Wang Qun, Wu Jianping
School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China.
Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Brain Sci. 2021 Sep 26;11(10):1276. doi: 10.3390/brainsci11101276.
Acid-base homeostasis is crucial for numerous physiological processes. Na+/HCO3- cotransporters (NBCs) belong to the solute carrier 4 (SLC4) family, which regulates intracellular pH as well as HCO3- absorption and secretion. However, knowledge of the structural functions of these proteins remains limited. Electrogenic NBC (NBCe-1) is thought to be the primary factor promoting the precise acid-base equilibrium in distinct cell types for filtration and reabsorption, as well as the function of neurons and glia. NBC dysregulation is strongly linked to several diseases. As such, the need for special drugs that interfere with the transmission function of NBC is becoming increasingly urgent. In this review, we focus on the structural and functional characteristics of NBCe1, and discuss the roles of NBCe1 in the kidney, central nervous system (CNS), and related disorders, we also summarize the research on NBC inhibitors. NBCe1 and the related pathways should be further investigated, so that new medications may be developed to address the related conditions.
酸碱平衡对于众多生理过程至关重要。钠/碳酸氢根共转运体（NBCs）属于溶质载体4（SLC4）家族，该家族调节细胞内pH以及碳酸氢根的吸收和分泌。然而，关于这些蛋白质结构功能的了解仍然有限。电中性NBC（NBCe-1）被认为是促进不同细胞类型中精确酸碱平衡以进行滤过和重吸收以及神经元和神经胶质细胞功能的主要因素。NBC失调与多种疾病密切相关。因此，对干扰NBC传递功能的特殊药物的需求变得越来越迫切。在本综述中，我们聚焦于NBCe1的结构和功能特征，并讨论NBCe1在肾脏、中枢神经系统（CNS）及相关疾病中的作用，我们还总结了关于NBC抑制剂的研究。应进一步研究NBCe1及相关途径，以便开发新药物来治疗相关病症。
