Laghouaouta Houda, Pena Ramona N, Ros-Freixedes Roger, Reixach Josep, Díaz Marta, Estany Joan, Armengol Ramon, Bassols Anna, Fraile Lorenzo
Agrotecnio-CERCA Center, Department of Animal Science, University of Lleida, 25198 Lleida, Spain.
Selección Batallé SA, 17421 Riudarenes, Spain.
Animals (Basel). 2021 Oct 15;11(10):2970. doi: 10.3390/ani11102970.
There is a growing concern about the genetic determinism of resilience and its possible implementation in breeding programs. The objective of our study was to elaborate novel resilience indicators in growing pigs based on the deviation from the expected growth curve and the increment of the acute-phase protein haptoglobin (HP) after applying a common vaccine. A total of 445 pigs were vaccinated with an attenuated Aujeszky vaccine at 12 weeks of age. Deviation from the expected body weight (ΔBW) given the growth curve of unvaccinated pigs at 28 days post-vaccination (DPV) and the increment of HP at 4 DPV (ΔHP) were suggested as resilience indicators. Challenged pigs that maintained their productivity and had a minor activation of HP were deemed resilient, whereas pigs that had low ∆BW values and a high activation of HP were deemed susceptible. Pigs were also classified based on ∆BW and ∆HP relative to the expected BW at 28 DPV and to the basal level of HP, respectively. The concordance was high between both methods, indicating that ΔBW and ΔHP are not sensitive to the animal's expected BW nor the basal level of HP. The heritability estimates were moderate for ∆BW (0.33) and low-to-moderate for ∆HP (0.16). Our study suggests ΔBW and ΔHP as novel resilience indicators in pigs. The suggested indicators capture different aspects of resilience, are easy to measure, and are genetically controlled. Thus, they may be improved through selective breeding. Further analyses are needed to validate our findings.
人们越来越关注恢复力的遗传决定因素及其在育种计划中的可能应用。我们研究的目的是基于与预期生长曲线的偏差以及接种普通疫苗后急性期蛋白触珠蛋白（HP）的增量，制定生长猪新的恢复力指标。总共445头猪在12周龄时接种了减毒奥耶斯基疫苗。以接种疫苗后28天（DPV）未接种疫苗猪的生长曲线为依据的预期体重偏差（ΔBW）和4 DPV时HP的增量（ΔHP）被建议作为恢复力指标。维持其生产力且HP激活程度较低的受挑战猪被视为具有恢复力，而ΔBW值低且HP激活程度高的猪被视为易感性猪。猪还分别根据相对于28 DPV时预期体重的ΔBW和相对于HP基础水平的ΔHP进行分类。两种方法之间的一致性很高，表明ΔBW和ΔHP对动物的预期体重和HP基础水平均不敏感。ΔBW的遗传力估计值为中等（0.33），ΔHP的遗传力估计值为低到中等（0.16）。我们的研究建议将ΔBW和ΔHP作为猪新的恢复力指标。所建议的指标涵盖了恢复力的不同方面，易于测量，且受遗传控制。因此，它们可以通过选择性育种得到改善。需要进一步分析来验证我们的研究结果。
