ProGene Technologies Pty Ltd., Macquarie Park, Sydney, NSW 2113, Australia.
Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, North Ryde, Sydney, NSW 2109, Australia.
Biomolecules. 2021 Sep 27;11(10):1411. doi: 10.3390/biom11101411.
Cannabis (), popularly known as marijuana, is the most commonly used psychoactive substance and is considered illicit in most countries worldwide. However, a growing body of research has provided evidence of the therapeutic properties of chemical components of cannabis known as cannabinoids against several diseases including Alzheimer's disease (AD), multiple sclerosis (MS), Parkinson's disease, schizophrenia and glaucoma; these have prompted changes in medicinal cannabis legislation. The relaxation of legal restrictions and increased socio-cultural acceptance has led to its increase in both medicinal and recreational usage. Several biochemically active components of cannabis have a range of effects on the biological system. There is an urgent need for more research to better understand the molecular and biochemical effects of cannabis at a cellular level, to understand fully its implications as a pharmaceutical drug. Proteomics technology is an efficient tool to rigorously elucidate the mechanistic effects of cannabis on the human body in a cell and tissue-specific manner, drawing conclusions associated with its toxicity as well as therapeutic benefits, safety and efficacy profiles. This review provides a comprehensive overview of both in vitro and in vivo proteomic studies involving the cellular and molecular effects of cannabis and cannabis-derived compounds.
大麻（Cannabis），俗称 marijuana，是最常用的精神活性物质，在世界上大多数国家被视为非法药物。然而，越来越多的研究证据表明，大麻的化学成分——大麻素具有治疗多种疾病的特性，包括阿尔茨海默病（AD）、多发性硬化症（MS）、帕金森病、精神分裂症和青光眼；这些证据促使各国修改了医用大麻法规。法律限制的放宽和社会文化接受度的提高，导致大麻在医用和娱乐用方面的使用都有所增加。大麻的几种生物化学活性成分对生物系统有多种影响。我们迫切需要开展更多的研究，以便在细胞水平上更好地了解大麻的分子和生化作用，从而全面了解它作为一种药物的含义。蛋白质组学技术是一种有效的工具，可以严格阐明大麻对人体的细胞和组织特异性的作用机制，得出与毒性以及治疗益处、安全性和疗效特征相关的结论。本综述全面概述了涉及大麻和大麻衍生化合物的细胞和分子作用的体外和体内蛋白质组学研究。
