Nelson Adam, Lukacs Jordan D, Johnston Brent
Department of Microbiology and Immunology, Dalhousie University, Halifax, NS B3H 4R2, Canada.
Beatrice Hunter Cancer Research Institute, Halifax, NS B3H 4R2, Canada.
Cancers (Basel). 2021 Oct 15;13(20):5174. doi: 10.3390/cancers13205174.
NKT cells are a specialized subset of lipid-reactive T lymphocytes that play direct and indirect roles in immunosurveillance and anti-tumor immunity. Preclinical studies have shown that NKT cell activation via delivery of exogenous glycolipids elicits a significant anti-tumor immune response. Furthermore, infiltration of NKT cells is associated with a good prognosis in several cancers. In this review, we aim to summarize the role of NKT cells in cancer as well as the current strategies and status of NKT cell immunotherapy. This review also examines challenges and future directions for improving the therapy.
NKT细胞是脂质反应性T淋巴细胞的一个特殊亚群，在免疫监视和抗肿瘤免疫中发挥直接和间接作用。临床前研究表明，通过递送外源性糖脂激活NKT细胞可引发显著的抗肿瘤免疫反应。此外，NKT细胞浸润与多种癌症的良好预后相关。在这篇综述中，我们旨在总结NKT细胞在癌症中的作用以及NKT细胞免疫疗法的当前策略和现状。本综述还探讨了改善该疗法的挑战和未来方向。
