Rychlik Agnieszka, Querleu Denis, Bidzinski Mariusz
Department of Gynaecologic Oncology, National Research Institute of Oncology, 02-781 Warsaw, Poland.
Department of Obstetrics and Gynecology, University of Strasbourg, 67081 Strasbourg, France.
Cancers (Basel). 2021 Oct 15;13(20):5177. doi: 10.3390/cancers13205177.
Fertility sparing management of cancer is one of the main components of quality-of-life issues. Early-stage cervical cancer, frequently diagnosed in women of reproductive age, can potentially be treated conservatively. However, some rare histological types of cervical cancer present with aggressive clinical behavior. Particularly, in the newly introduced concept of gastric-type endocervical carcinoma, fertility sparing management is 'a priori' not recommended. Even so, this issue remains undocumented. For this reason, a selected review of the current literature on gastric type endocervical carcinoma was carried out through PubMed. The keywords included "gastric-type cervical cancer", "gastric-type endocervical carcinoma", "conservative surgery", "conservative treatment", "fertility sparing surgery", "radical trachelectomy", "laparoscopic trachelectomy", "robotic trachelectomy", "laparotomic trachelectomy", "abdominal trachelectomy", "trachelectomy", "neoadjuvant chemotherapy", "conisation", and "cone resection". A search in the European Network on Cancer, Infertility and Pregnancy (INCIP) database was performed. The rarity of gastric-type endocervical carcinoma does not allow for conclusions on fertility sparing management with solid evidence. However, diffuse character of the disease and aggressive clinical behavior contraindicate a conservative treatment in young women with gastric type cervical cancer.
癌症的保留生育功能管理是生活质量问题的主要组成部分之一。早期宫颈癌在育龄女性中经常被诊断出来,有可能采用保守治疗。然而,一些罕见组织学类型的宫颈癌具有侵袭性临床行为。特别是在新引入的胃型宫颈内膜癌概念中,不“先验地”推荐保留生育功能管理。即便如此,这个问题仍未被记录在案。因此,通过PubMed对当前关于胃型宫颈内膜癌的文献进行了选定综述。关键词包括“胃型宫颈癌”、“胃型宫颈内膜癌”、“保守手术”、“保守治疗”、“保留生育功能手术”、“根治性宫颈切除术”、“腹腔镜宫颈切除术”、“机器人辅助宫颈切除术”、“开腹宫颈切除术”、“经腹宫颈切除术”、“宫颈切除术”、“新辅助化疗”、“锥形切除术”和“宫颈锥切术”。在欧洲癌症、不孕与妊娠网络(INCIP)数据库中进行了检索。胃型宫颈内膜癌的罕见性使得无法得出有确凿证据支持的保留生育功能管理的结论。然而,该疾病的弥漫性特征和侵袭性临床行为表明,对于患有胃型宫颈癌的年轻女性,不适合进行保守治疗。