Yang Yiming, Sanders Andrew J, Dou Q Ping, Jiang David G, Li Amber Xinyu, Jiang Wen G
School of Medicine, Cardiff University, Henry Wellcome Building, Cardiff CF14 4XN, UK.
Departments of Oncology, Pharmacology and Pathology School of Medicine, Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201-2013, USA.
Cancers (Basel). 2021 Oct 15;13(20):5187. doi: 10.3390/cancers13205187.
Activated leukocyte cell adhesion molecule (ALCAM), also known as CD166, is a cell adhesion protein that is found in multiple cell types. ALCAM has multiple and diverse roles in various physiological and pathological conditions, including inflammation and cancer. There has been compelling evidence of ALCAM's prognostic value in solid cancers, indicating that it is a potential therapeutic target. The present article overviews the recent findings and progress in ALCAM and its involvement in cancer, with a primary focus on its clinical connections in cancer and therapeutic values.
活化白细胞细胞黏附分子（ALCAM），也称为CD166，是一种在多种细胞类型中发现的细胞黏附蛋白。ALCAM在各种生理和病理状况中，包括炎症和癌症，具有多种不同的作用。有令人信服的证据表明ALCAM在实体癌中具有预后价值，这表明它是一个潜在的治疗靶点。本文综述了ALCAM的最新研究结果和进展及其与癌症的关系，主要关注其在癌症中的临床联系和治疗价值。
