新型二氢-1-吡唑并[1,3-]吡啶恩贝林衍生物的模块化合成及抗增殖活性
Modular Synthesis and Antiproliferative Activity of New Dihydro-1-pyrazolo[1,3-]pyridine Embelin Derivatives.
作者信息
Martín-Acosta Pedro, Amesty Ángel, Guerra-Rodríguez Miguel, Guerra Borja, Fernández-Pérez Leandro, Estévez-Braun Ana
机构信息
Departamento de Química Orgánica, Instituto Universitario de Bio-Orgánica Antonio González, Universidad de La Laguna, Avda. Astrofísico Francisco Sánchez No. 2, 38206 Tenerife, Spain.
Instituto Universitario de Investigaciones Biomédicas y Sanitarias (IUIBS), Farmacología Molecular y Traslacional (BIOPharm), Universidad de Las Palmas de Gran Canaria (ULPGC), 35001 Las Palmas de Gran Canaria, Spain.
出版信息
Pharmaceuticals (Basel). 2021 Oct 8;14(10):1026. doi: 10.3390/ph14101026.
A set of new dihydro-1-pyrazolo[1,3-]pyridine and pyrazolo[1,3-]pyridine embelin derivatives was synthesized through a multicomponent reaction from natural embelin, 3-substituted-5-aminopyrazoles and aldehydes. The synthesized compounds were evaluated against three hematologic tumor cell lines, HEL (acute erythroid leukemia), K-562 (chronic myeloid leukemia) and HL-60 (acute myeloid leukemia), and five breast cancer cell lines (SKBR3, MCF-7, MDA-MB-231, BT-549, HS-578T). The primate non-malignant kidney Vero cell line was used as the control of cytotoxicity. From the obtained results, some structure-activity relationships were outlined. Furthermore, in silico prediction of physicochemical properties and ADME parameters were determined for the derivatives with the best antiproliferative values.
通过天然紫铆素、3-取代-5-氨基吡唑和醛的多组分反应合成了一组新的二氢-1-吡唑并[1,3-]吡啶和吡唑并[1,3-]吡啶紫铆素衍生物。对合成的化合物针对三种血液肿瘤细胞系（HEL，急性红白血病；K-562，慢性髓性白血病；HL-60，急性髓性白血病）和五种乳腺癌细胞系（SKBR3、MCF-7、MDA-MB-231、BT-549、HS-578T）进行了评估。灵长类非恶性肾Vero细胞系用作细胞毒性对照。根据所得结果，概述了一些构效关系。此外，还对具有最佳抗增殖值的衍生物进行了理化性质和ADME参数的计算机模拟预测。
Zotero 插件