Mulder G R, van Amerongen W E, Vingerling P A
ASDC J Dent Child. 1987 Jan-Feb;54(1):35-9.
In the context of a study of the development of enamel lesions in permanent successors of primary molars treated by formocresol pulpotomy, a comparative clinical study was performed of 278 premolars divided equally between test side and control side. These teeth were assessed by two observers who, when finding enamel lesions, always differentiated between opacities and hypoplasias. The principal conclusions from this study are the following: The degree of agreement between the two observers was 96 percent. There was no significant difference in number of teeth with enamel lesions, between test side and control side. When the observed teeth with enamel lesions were related to the age at which pulpotomy was performed, the difference was still insignificant. Separate comparison of opacities and hypoplasias likewise showed no significant differences, even if related to age at which pulpotomy was performed. A formocresol pulpotomy exerts no influence on the size of enamel lesions found in permanent successors of the teeth on which pulpotomies were performed. The general conclusion from the results of this study is that formocresol pulpotomy is a successful technique for the treatment of primary teeth, not only as regards the life-span of these primary teeth (see Part I of the study) but also in terms of its effect on their permanent successors.
在一项关于用甲醛甲酚牙髓切断术治疗的乳磨牙恒牙继承牙釉质病变发展的研究中，对278颗前磨牙进行了一项对比临床研究，试验侧和对照侧各占一半。由两名观察者对这些牙齿进行评估，他们在发现牙釉质病变时，总能区分牙釉质混浊和发育不全。这项研究的主要结论如下：两名观察者之间的一致程度为96%。试验侧和对照侧有牙釉质病变的牙齿数量没有显著差异。当观察到的有牙釉质病变的牙齿与进行牙髓切断术时的年龄相关时，差异仍然不显著。即使与进行牙髓切断术时的年龄相关，分别比较牙釉质混浊和发育不全也同样没有显著差异。甲醛甲酚牙髓切断术对接受牙髓切断术牙齿的恒牙继承牙中发现的牙釉质病变大小没有影响。这项研究结果的总体结论是，甲醛甲酚牙髓切断术是一种治疗乳牙的成功技术，不仅在这些乳牙的寿命方面（见研究的第一部分），而且在其对恒牙继承牙的影响方面。
