Matsumoto Y, Hitsuda Y, Sugimoto Y, Ishikawa J, Sasaki T
Jpn J Antibiot. 1986 Oct;39(10):2690-4.
In 5 patients with respiratory tract infections, concentrations of cefotetan (CTT) in serum and sputum after 1 hour intravenous administration of 2 g of CTT to each patient were investigated, and following results were obtained. Serum levels of CTT The mean peak level of CTT was 232.0 +/- 16.2 micrograms/ml immediately after the 1 hour drip infusion, then declined gradually and was 48.0 +/- 8.8 micrograms/ml after 6 hours. Sputum levels of CTT Mean sputum levels of CTT were 2.15 +/- 0.19 micrograms/ml from 2 to 4 hours after the administration and 2.19 +/- 0.18 micrograms/ml from 4 to 6 hours. Clinical evaluation of CTT Clinical effects were excellent in 1 case, good in 3 cases and poor in 1 case. No side effects were observed.
对5例呼吸道感染患者，在静脉注射2克头孢替坦（CTT）1小时后，对血清和痰液中CTT浓度进行了研究，结果如下。CTT血清水平：在1小时静脉滴注后即刻，CTT的平均峰值水平为232.0±16.2微克/毫升，随后逐渐下降，6小时后为48.0±8.8微克/毫升。CTT痰液水平：给药后2至4小时，CTT的平均痰液水平为2.15±0.19微克/毫升，4至6小时为2.19±0.18微克/毫升。CTT的临床评估：临床效果1例为优，3例为良，1例为差。未观察到副作用。
