Oral Medicine and Surgery Unit, Faculty of Dentistry, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Instituto de Investigación Sanitaria de Santiago (IDIS), 15782 Santiago de Compostela, Spain.
Medicina (Kaunas). 2021 Oct 12;57(10):1092. doi: 10.3390/medicina57101092.
: The purpose of this study was to analyse the diagnostic and prognostic efficiency of the sentinel lymph node biopsy technique (SLNB). : This is a prospective observational study performed by the Hospital Complex in Santiago de Compostela (CHUS) in Spain, between February 2013 and June 2020. The study included 60 patients, who had been diagnosed with OSCC in stage T1/T2N0M0. : 10 patients (16.7%) presented with SN+ (sentinel node positive). The majority (80%) only presented subcapsular affection, however one case also presented with extracapsular affection. Using the Kaplan-Meier curves, we determined that the average survival estimation for SN- patients was 74.0 months (CI95% 67.6-80.5) and it was 45.4 months (CI95% 10.9-24.0) for SN+ patients ( = 0.002). SN+ patients presented an OR = 11.000 (CI95% 2.393-50.589, = 0.002) for cancer-related mortality. In terms of the diagnostic performance of the SN (sentinel node) test, a 55% sensitivity, a 100% specificity, 100% PPV and a 84% NPV were obtained. The analysis using ROC (receiver operating characteristic) curves revealed an AUC = 0.671 (CI95% 0.492-0.850, = 0.046). : SLNB seems to be an adequate technique for the detection of hidden metastases.
: 本研究旨在分析前哨淋巴结活检技术（SLNB）的诊断和预后效率。: 这是一项在西班牙圣地亚哥德孔波斯特拉综合医院（CHUS）进行的前瞻性观察研究，时间为 2013 年 2 月至 2020 年 6 月。研究纳入了 60 例 T1/T2N0M0 期 OSCC 患者。: 10 例（16.7%）患者 SN+（前哨淋巴结阳性）。大多数（80%）仅表现为包膜下累及，然而，有 1 例还伴有包膜外累及。通过 Kaplan-Meier 曲线，我们确定 SN-患者的平均生存估计为 74.0 个月（95%CI 67.6-80.5），而 SN+患者为 45.4 个月（95%CI 10.9-24.0）（ = 0.002）。SN+患者的癌症相关死亡率的 OR = 11.000（95%CI 2.393-50.589， = 0.002）。就 SN（前哨淋巴结）检测的诊断性能而言，获得了 55%的灵敏度、100%的特异性、100%的阳性预测值和 84%的阴性预测值。ROC（接受者操作特征）曲线分析显示 AUC = 0.671（95%CI 0.492-0.850， = 0.046）。: SLNB 似乎是一种检测隐匿性转移的有效技术。
