Ewha Brain Institute, Ewha Womans University, Seoul, South Korea.
Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, South Korea.
Eur J Neurosci. 2021 Nov;54(10):7550-7559. doi: 10.1111/ejn.15505. Epub 2021 Nov 10.
Growing evidence indicates that type 2 diabetes mellitus (T2DM)-related cognitive dysfunction may develop in the early stage of the disease and is often accompanied by hippocampal structural alterations. In the current study, we investigated volume and shape alterations of the hippocampus at a subregional level in patients with T2DM. With the use of high-resolution brain structural images that were obtained from 30 T2DM patients with less than 5 years of disease duration and 30 healthy individuals, volumetric and shape analyses were performed. We also assessed the relationship between T2DM-related hippocampal structural alterations and performance on verbal fluency. In volumetric analysis, total hippocampal volume was smaller in the T2DM group, relative to the control group. At a subregional level, T2DM patients showed significant inward deformation and volume reduction of the right dentate gyrus and cornu ammonis 2/3 subregions as compared with healthy individuals. In particular, T2DM patients with lower performance on verbal fluency had smaller right dentate gyrus volumes relative to those with higher performance. These findings suggest that the hippocampus may undergo atrophy at a subregional level even in the early stage of T2DM, and this subregion-specific atrophy may be associated with reduced performance on verbal fluency.
越来越多的证据表明，2 型糖尿病（T2DM）相关的认知功能障碍可能在疾病早期发展，并且常伴有海马结构改变。在本研究中，我们研究了 T2DM 患者海马亚区水平的体积和形状改变。我们使用来自 30 名病程少于 5 年的 T2DM 患者和 30 名健康个体的高分辨率脑结构图像，进行了容积和形状分析。我们还评估了 T2DM 相关的海马结构改变与语言流畅性表现之间的关系。在体积分析中，T2DM 组的总海马体积小于对照组。在亚区水平，与健康个体相比，T2DM 患者右侧齿状回和角回 2/3 亚区表现出明显的内陷变形和体积减小。特别是，语言流畅性表现较低的 T2DM 患者右侧齿状回体积小于表现较高的患者。这些发现表明，即使在 T2DM 的早期阶段，海马也可能在亚区水平发生萎缩，这种特定亚区的萎缩可能与语言流畅性表现降低有关。
